Features include always present findings: Poor speech, Narrow forehead, Strabismus, and Short foot and others; and rarely findings: Fragile nails. 27 total HPO annotations.

CAMK2G encodes calcium/calmodulin dependent protein kinase II gamma (558 aa). Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. Highest expression in Artery Tibial (127.1 TPM) and Colon Sigmoid (115.7 TPM).

Intellectual developmental disorder 59 has limited evidence linking it to mutations in the CAMK2G gene on chromosome 10.

The CAMK2G protein participates in p-CAMK2D, p-CAMK2G pathway.

CAMK2G is classified as a druggable target (Druggable Genome, Enzyme, Kinase, and Serine Threonine Kinase categories) with score 1.2.

Genetic testing for CAMK2G is available. Testing is considered research-grade for diagnosis.

Biomarker and diagnostic research for intellectual developmental disorder 59 has been reported in the published literature.

Phenotype severity distribution: 15 always present features.

No clinical trials have been registered for intellectual developmental disorder 59.

201 publications have been identified in PubMed for intellectual developmental disorder 59. Kisho has analyzed 81 by research type. Research spans Epidemiology / Natural History (37%), Review / Meta-Analysis (25%), and Basic Science / Preclinical (19%).