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intellectual disability-obesity-prognathism-eye and skin anomalies syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

intellectual disability-obesity-prognathism-eye and skin anomalies syndrome

MONDO:0011722

Also known as:MOMES syndromeintellectual disability, obesity, mandibular prognathism, and eye and skin anomaliesmental retardation, obesity, mandibular prognathism, and eye and skin anomalies

Overview

GeneticsAutosomal recessive

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Hyperopic astigmatism, Delayed speech and language development, Atopic dermatitis, and Blepharophimosis and 13 more.

Organ System	Phenotype Count	Example Features
Brain and nerves	2	Delayed speech and language development, Intellectual disability

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for intellectual disability-obesity-prognathism-eye and skin anomalies syndrome.

46 publications have been identified in PubMed for intellectual disability-obesity-prognathism-eye and skin anomalies syndrome. Research spans Case Report / Case Series (54%), Review / Meta-Analysis (31%), and Basic Science / Preclinical (13%).

Research Type	Count	% of Total
Patient case studies	21	54%

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 9:50 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:606772

Orphanet

European rare disease database

Orphanet:397973

GARD

Genetic and Rare Diseases Info Center

GARD:17648

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

intellectual disability-obesity-prognathism-eye and skin anomalies syndrome

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

intellectual disability-obesity-prognathism-eye and skin anomalies syndrome

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications