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Invasive non-typhoidal salmonellosis (iNTS) is a rare bacterial infectious disease caused by extraintestinal infection of non-typhoidal serotypes of Salmonella enterica in patients with underlying HIV infection, malaria or malignancy. It has a high mortality rate and patients typically present with fever, pallor and respiratory signs (cough, tachnypnea, pneumonia). Gastrointestinal manifestations (diarrhea, vomit, abdominal pain) are not common. Occasionally, organ absseses, septic shock and meningitis may be observed.
Biomarker and diagnostic research for invasive non-typhoidal salmonellosis has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
2 clinical trials registered, 1 recruiting. Interventions under study include biologic therapy. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.
25 publications have been identified in PubMed for invasive non-typhoidal salmonellosis. Research spans Epidemiology / Natural History (44%), Basic Science / Preclinical (16%), and Gene Therapy / Novel Therapeutics (16%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 11 |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:09 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Laboratory research | 4 | 16% |
New treatment approaches | 4 | 16% |
Research summaries | 3 | 12% |
Patient case studies | 2 | 8% |
Testing and diagnosis research | 1 | 4% |
Osorio-Barrios F (2026). [PMID: 41046209](https://pubmed.ncbi.nlm.nih.gov/41046209/). *Trends in immunology*. [Basic Science / Preclinical]
Gunarathna S (2026). [PMID: 41673391](https://pubmed.ncbi.nlm.nih.gov/41673391/). *NPJ vaccines*. [Gene Therapy / Novel Therapeutics]
Spasenoska D (2026). [PMID: 41730005](https://pubmed.ncbi.nlm.nih.gov/41730005/). *PLoS neglected tropical diseases*. [Epidemiology / Natural History]
Jia C (2026). [PMID: 41803129](https://pubmed.ncbi.nlm.nih.gov/41803129/). *Nature communications*. [Epidemiology / Natural History]
Revie NM (2026). [PMID: 41702319](https://pubmed.ncbi.nlm.nih.gov/41702319/). *Vaccine*. [Epidemiology / Natural History]
Ranjan A (2026). [PMID: 42075213](https://pubmed.ncbi.nlm.nih.gov/42075213/). *Microorganisms*. [Review / Meta-Analysis]
Collins ME (2026). [PMID: 42120675](https://pubmed.ncbi.nlm.nih.gov/42120675/). *Eur J Clin Microbiol Infect Dis*. [Case Report / Case Series]
Pulford CV (2025). [PMID: 40720975](https://pubmed.ncbi.nlm.nih.gov/40720975/). *The Lancet. Microbe*. [Epidemiology / Natural History]
Lizarazo J (2025). [PMID: 41244289](https://pubmed.ncbi.nlm.nih.gov/41244289/). *ASM case reports*. [Case Report / Case Series]
He Y (2025). [PMID: 40168434](https://pubmed.ncbi.nlm.nih.gov/40168434/). *PLoS neglected tropical diseases*. [Epidemiology / Natural History]
AI-curated news mentioning invasive non-typhoidal salmonellosis
Updated Aug 1, 2026
A genomic analysis of Salmonella enterica serovar Dublin reveals insights into its transmission among dairy cattle, dogs, and humans in Florida from 2019 to 2024. This research may inform future strategies for managing outbreaks and understanding cross-species infections.
A 2024 outbreak of Salmonella Agbeni has been linked to ice in a cooler at a county fair in Illinois. This incident highlights the ongoing public health challenges associated with food safety at community events.
A recent study provides genomic characterization of Salmonella enterica serotype Saintpaul isolates from horses, contributing to the understanding of this pathogen's genetic diversity. This research may inform future strategies for managing infections in equine populations.