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isolated congenital adermatoglyphia (ADG) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

isolated congenital adermatoglyphia

MONDO:0007619

Also known as:ADGabsence of fingerprintsadermatoglyphia

Overview

Isolated congenital adermatoglyphia is a rare, genetic develomental defect during embryogenesis disorder characterized by the lack of epidermal ridges on the palms and soles, resulting in the absence of fingerprints, with no other associated manifestations. It is associated with a reduced number of sweat gland openings and reduced transpiration of palms and soles.

GeneticsAutosomal dominant · SMARCAD1 (chr 4)

ResearchLimited published research (4 articles)

Clinical Presentation

Features include: Clubbing, Adermatoglyphia, and Palmar hyperkeratosis.

Organ System	Phenotype Count	Example Features
Skin	1	Palmar hyperkeratosis

Explore clinical features

Genetic Landscape

SMARCAD1 function has not been fully characterized.

Isolated congenital adermatoglyphia is associated with mutations in the SMARCAD1 gene on chromosome 4.

Diagnosis

Genetic testing for SMARCAD1 is available. Testing is considered confirmatory for diagnosis.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for isolated congenital adermatoglyphia.

4 publications have been identified in PubMed for isolated congenital adermatoglyphia. Research spans Case Report / Case Series (50%), Review / Meta-Analysis (25%), and Basic Science / Preclinical (25%).

Recent Publications

Deng G (2026). [PMID: 41658620](https://pubmed.ncbi.nlm.nih.gov/41658620/). *Frontiers in medicine*. [Case Report / Case Series]
Asghar N (2025). [PMID: 40634789](https://pubmed.ncbi.nlm.nih.gov/40634789/). *Biochemical genetics*. [Basic Science / Preclinical]
Belloni S (2025). [PMID: 40037149](https://pubmed.ncbi.nlm.nih.gov/40037149/). *Seminars in oncology*. [Review / Meta-Analysis]
Bansal S (2024). [PMID: 38765347](https://pubmed.ncbi.nlm.nih.gov/38765347/). *Cureus*. [Case Report / Case Series]

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 6:54 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:136000

Orphanet

European rare disease database

Orphanet:289465

GARD

Genetic and Rare Diseases Info Center

GARD:12550

Questions for Your Care Team

→Should I pursue genetic testing for SMARCAD1, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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isolated congenital adermatoglyphia

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team