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Hyperkeratosis-hyperpigmentation syndrome describes a very rare hyperpigmentation of the skin characterized by tiny hyperpigmented spots mainly on skin exposed to sunlight, together with mild punctate palmoplantar papular hyperkeratosis as a major feature. There have been no further descriptions in the literature since 1993.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for hyperkeratosis-hyperpigmentation syndrome.
2 publications have been identified in PubMed for hyperkeratosis-hyperpigmentation syndrome. Research spans Other (50%) and Case Report / Case Series (50%).
Fu S (2026). [PMID: 41717332](https://pubmed.ncbi.nlm.nih.gov/41717332/). *Frontiers in toxicology*. [Case Report / Case Series]
Priyadhashini BV (2024). [PMID: 39119318](https://pubmed.ncbi.nlm.nih.gov/39119318/). *Indian journal of dermatology*. [Other]
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 5:26 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center