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osteopathia striata-pigmentary dermopathy-white forelock syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

osteopathia striata-pigmentary dermopathy-white forelock syndrome

MONDO:0017197

Also known as:Whyte-Murphy syndromeosteopathia striata associated with familial dermopathy and white forelockosteopathia striata with pigmentary dermopathy including white forelock

Overview

Osteopathia striata-pigmentary dermopathy-white forelock syndrome is characterized by the association of osteopathia striata (longitudinal striations through most of the long bones) with a macular, hyperpigmented dermopathy and a white forelock.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Abnormal diaphysis morphology, Abnormal metaphysis morphology, White forelock, and Abnormal pelvic girdle bone morphology and others.

Organ System	Phenotype Count	Example Features
Bones and joints	2	Abnormal pelvic girdle bone morphology, Osteopathia striata

Diagnosis

Biomarker and diagnostic research for osteopathia striata-pigmentary dermopathy-white forelock syndrome has been reported in the published literature.

Prognosis

Phenotype severity distribution: 7 very common features.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for osteopathia striata-pigmentary dermopathy-white forelock syndrome.

129 publications have been identified in PubMed for osteopathia striata-pigmentary dermopathy-white forelock syndrome. Research spans Review / Meta-Analysis (69%), Basic Science / Preclinical (14%), and Epidemiology / Natural History (7%).

Research Type	Count	% of Total
Research summaries	89	69%

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 6:26 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:2779

GARD

Genetic and Rare Diseases Info Center

GARD:5562

Questions for Your Care Team

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osteopathia striata-pigmentary dermopathy-white forelock syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

osteopathia striata-pigmentary dermopathy-white forelock syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications