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Isolated aglossia and hypoglossia are terms covering the spectrum from partial to total absence of the tongue. These congenital malformations have been classified as part of the group of oromandibular-limb hypogenesis syndromes (OLHS).
Features include very common findings: Delayed speech and language development, Dyspnea, Nasogastric tube feeding in infancy, and Feeding difficulties; and common findings: Respiratory distress, Microglossia, Upper airway obstruction, and Micrognathia and others. 25 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Lungs and breathing | 4 | Respiratory distress, Upper airway obstruction, Dyspnea |
Phenotype severity distribution: 4 very common features, 7 common features.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for isolated congenital hypoglossia/aglossia.
2 publications have been identified in PubMed for isolated congenital hypoglossia/aglossia. Research spans Case Report / Case Series (100%).
Velisavljev-Filipovic GM (2025). [PMID: 40709982](https://pubmed.ncbi.nlm.nih.gov/40709982/). *Diseases*. [Case Report / Case Series]
Jha M (2024). [PMID: 39822794](https://pubmed.ncbi.nlm.nih.gov/39822794/). *J Clin Exp Dent*. [Case Report / Case Series]
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 6:47 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Digestive system | 3 | Feeding difficulties in infancy, Feeding difficulties, Gastrostomy tube feeding in infancy |
Head and neck | 2 | High palate, Cleft palate |
Brain and nerves | 1 | Delayed speech and language development |
Growth and development | 1 | Weight loss |
Arms and legs | 1 | Aplasia/Hypoplasia of fingers |
Bones and joints | 1 | Temporomandibular joint ankylosis |
AI-curated news mentioning isolated congenital hypoglossia/aglossia
Updated Feb 10, 2024
A case report details Oromandibular Limb Hypogenesis Syndrome Type IVB, highlighting its association with hypoglossia and intraoral bands. This rare entity contributes to the understanding of congenital anomalies and their clinical implications.