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Oromandibular-limb hypogenesis syndromes (OLHS) are a group of dysmorphic complexes (including Charlie M syndrome, Hanhart syndrome and glossopalatine ankylosis) characterized by the association of severe asymmetric limb defects (primarily involving distal segments) and abnormalities of the oral cavity and mandible (hypoglossia, aglossia, micrognathia, glossopalatine ankylosis, cleft palate, and gingival anomalies).
Estimated prevalence: 1-9 in 1,000,000 (Rare).
No clinical trials have been registered for oromandibular-limb hypogenesis syndrome.
4 publications have been identified in PubMed for oromandibular-limb hypogenesis syndrome. Research spans Case Report / Case Series (100%).
Anand R (2026). [PMID: 42206110](https://pubmed.ncbi.nlm.nih.gov/42206110/). *J Maxillofac Oral Surg*. [Case Report / Case Series]
Chopra S (2026). [PMID: 42148452](https://pubmed.ncbi.nlm.nih.gov/42148452/). *Front Dent Med*. [Case Report / Case Series]
Velisavljev-Filipovic GM (2025). [PMID: 40709982](https://pubmed.ncbi.nlm.nih.gov/40709982/). *Diseases*. [Case Report / Case Series]
Jha M (2024). [PMID: 39822794](https://pubmed.ncbi.nlm.nih.gov/39822794/). *J Clin Exp Dent*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 2:59 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
AI-curated news mentioning oromandibular-limb hypogenesis syndrome
Updated Feb 10, 2024
A case report details Oromandibular Limb Hypogenesis Syndrome Type IVB, highlighting its association with hypoglossia and intraoral bands. This rare entity contributes to the understanding of congenital anomalies and their clinical implications.