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juvenile nasopharyngeal angiofibroma (JNA) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

juvenile nasopharyngeal angiofibroma

MONDO:0017340

Also known as:JNAjuvenile nasopharyngeal angiofibroma (disease)nasopharyngeal angiofibroma

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Overview

Juvenile nasopharyngeal angiofibroma (JNA) is a rare and benign but locally aggressive fibrovascular tumor arising from the posterolateral wall of the nasopharynx, which affects mainly young and adolescent males (onset usually occurring between 7-19 years of age) and that presents as a mass in the nasopharynx and nasal cavity, leading to manifestations such as nasal obstruction, epistaxis, profound facial swelling, proptosis or diplopia. Although slowly progressive, it has a high rate of recurrence and sometimes invades adjacent structures.

Clinical Trials1 registered · 1 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Juvenile nasopharyngeal angiofibroma; and common findings: Facial edema, Epistaxis, Proptosis, and Diplopia and others. 8 total HPO annotations.

Organ System	Phenotype Count	Example Features
Head and neck	1	Facial edema

Diagnosis

Biomarker and diagnostic research for juvenile nasopharyngeal angiofibroma has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 always present feature, 5 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered, 1 recruiting. Interventions under study include drug therapy. Pipeline includes 1 PHASE3. Research is primarily sponsored by academic and government institutions.

65 publications have been identified in PubMed for juvenile nasopharyngeal angiofibroma. Research spans Case Report / Case Series (55%), Review / Meta-Analysis (15%), and Clinical Trial Publication (11%).

Research Type	Count	% of Total
Patient case studies	36

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 3:04 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:289596

GARD

Genetic and Rare Diseases Info Center

GARD:21144

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

juvenile nasopharyngeal angiofibroma

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

juvenile nasopharyngeal angiofibroma

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications