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juvenile xanthogranuloma (JXG) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

juvenile xanthogranuloma

MONDO:0015534

Also known as:JXGNaevoxanthoendotheliomamultiple eruptive juvenile xanthogranuloma

Find Clinical TrialsTrials

Overview

A benign histiocytic tumor that occurs during childhood; it is distinct from Langerhans cell histiocytosis. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells in the dermis. The lesions usually develop during infancy. They consist of cutaneous papules and nodules (most often in the head and neck). It is sometimes associated with deep soft tissues nodules.

Clinical Trials3 registered · 2 recruiting

Diagnosis

Biomarker and diagnostic research for juvenile xanthogranuloma has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered, 2 recruiting. Interventions under study include drug therapy, other interventions, and procedural interventions. Pipeline includes 3 PHASE2. Research is primarily sponsored by academic and government institutions.

67 publications have been identified in PubMed for juvenile xanthogranuloma. Research spans Case Report / Case Series (59%), Review / Meta-Analysis (23%), and Other (11%).

Research Type	Count	% of Total
Patient case studies	39

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 7:14 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:158000

GARD

Genetic and Rare Diseases Info Center

GARD:20020

Questions for Your Care Team

→Are any of the 3 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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juvenile xanthogranuloma

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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