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Group of disorders which feature accumulations of active HISTIOCYTES and LYMPHOCYTES, but where the histiocytes are not LANGERHANS CELLS. The group includes HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SINUS HISTIOCYTOSIS; xanthogranuloma; reticulohistiocytoma; juvenile XANTHOGRANULOMA; xanthoma disseminatum; as well as the lipid storage diseases (SEA-BLUE HISTIOCYTE SYNDROME; and NIEMANN-PICK DISEASES).
Biomarker and diagnostic research for non-Langerhans cell histiocytosis has been reported in the published literature.
2 clinical trials registered, 1 recruiting. Interventions under study include other interventions, drug therapy, and procedural interventions. Pipeline includes 1 PHASE2. Research is primarily sponsored by academic and government institutions.
141 publications have been identified in PubMed for non-Langerhans cell histiocytosis. Research spans Case Report / Case Series (77%), Review / Meta-Analysis (12%), and Other (4%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 109 |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 4:33 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries | 17 | 12% |
Other research | 6 | 4% |
Testing and diagnosis research | 4 | 3% |
Clinical study results | 3 | 2% |
Laboratory research | 1 | 1% |
Disease patterns and progression | 1 | 1% |
Xu AY (2026). [PMID: 41446685](https://pubmed.ncbi.nlm.nih.gov/41446685/). *JAAD Case Rep*. [Case Report / Case Series]
Soares Costa T (2026). [PMID: 41841069](https://pubmed.ncbi.nlm.nih.gov/41841069/). *Cureus*. [Case Report / Case Series]
Alfraiji AF (2026). [PMID: 42052528](https://pubmed.ncbi.nlm.nih.gov/42052528/). *Front Psychiatry*. [Case Report / Case Series]
Phong CH (2026). [PMID: 41852668](https://pubmed.ncbi.nlm.nih.gov/41852668/). *JAAD Case Rep*. [Case Report / Case Series]
Khalak S (2026). [PMID: 41820933](https://pubmed.ncbi.nlm.nih.gov/41820933/). *BMC Pediatr*. [Diagnostic / Biomarker]
Yilmaz B (2026). [PMID: 41489023](https://pubmed.ncbi.nlm.nih.gov/41489023/). *Am J Med Genet A*. [Case Report / Case Series]
Rahimi M (2026). [PMID: 41646162](https://pubmed.ncbi.nlm.nih.gov/41646162/). *Clin Case Rep*. [Case Report / Case Series]
El Fakih F (2026). [PMID: 41427798](https://pubmed.ncbi.nlm.nih.gov/41427798/). *Retin Cases Brief Rep*. [Case Report / Case Series]
Haq M (2026). [PMID: 41608151](https://pubmed.ncbi.nlm.nih.gov/41608151/). *World J Clin Cases*. [Case Report / Case Series]
Ferraz R (2026). [PMID: 41842676](https://pubmed.ncbi.nlm.nih.gov/41842676/). *Arch Argent Pediatr*. [Case Report / Case Series]
AI-curated news mentioning non-Langerhans cell histiocytosis
Updated May 4, 2026
A recent study evaluates the efficacy and tolerance of Cladribine for treating non-Langerhans cell histiocytosis. The findings contribute to understanding treatment options for this rare disease.