Features include always present findings: Neurofibrillary tangles. 5 total HPO annotations.

APOE encodes apolipoprotein E (317 aa). APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. Highest expression in Adrenal Gland (3,543 TPM) and Liver (3,182 TPM).

Alzheimer disease 2 is associated with mutations in the APOE gene on chromosome 19.

APOE is classified as a druggable target (Druggable Genome category) with score 0.9.

Genetic testing for APOE is available. Testing is considered confirmatory for diagnosis.

Phenotype severity distribution: 1 always present feature.

5 clinical trials registered, 2 recruiting. Interventions under study include other interventions, drug therapy, medical devices, and gene therapy. Pipeline includes 1 PHASE2, 1 NA. Research is sponsored by a mix of industry and academic institutions.