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lipoprotein glomerulopathy (LPG) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

lipoprotein glomerulopathy

MONDO:0012725

Also known as:LPG

Overview

GeneticsAPOE (chr 19)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Kidney filtering unit damage (glomerulopathy), Mesangial hypercellularity, Reduced kidney function (renal insufficiency), and Protein in the urine (proteinuria).

Organ System	Phenotype Count	Example Features
Kidneys and urinary system	3	Kidney filtering unit damage (glomerulopathy), Reduced kidney function (renal insufficiency), Protein in the urine (proteinuria)

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

APOE encodes apolipoprotein E (317 aa). APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. Highest expression in Adrenal Gland (3,543 TPM) and Liver (3,182 TPM).

Lipoprotein glomerulopathy is associated with mutations in the APOE gene on chromosome 19.

APOE is classified as a druggable target (Druggable Genome category) with score 0.9.

Diagnosis

Genetic testing for APOE is available. Testing is considered confirmatory for diagnosis.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for lipoprotein glomerulopathy.

20 publications have been identified in PubMed for lipoprotein glomerulopathy. Research spans Case Report / Case Series (60%), Review / Meta-Analysis (15%), and Other (10%).

Research Type	Count	% of Total
Patient case studies	12	60%

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 12:48 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:611771

Orphanet

European rare disease database

Orphanet:329481

GARD

Genetic and Rare Diseases Info Center

GARD:17504

Questions for Your Care Team

→Should I pursue genetic testing for APOE, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Kisho

lipoprotein glomerulopathy

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Progressive podocyte infolding glomerulopathy in a patient with systemic lupus erythematosus revealed by serial renal biopsies: a case report and literature review.

lipoprotein glomerulopathy

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Progressive podocyte infolding glomerulopathy in a patient with systemic lupus erythematosus revealed by serial renal biopsies: a case report and literature review.