Genetic testing for APOE is available. Testing is considered confirmatory for diagnosis.

Estimated prevalence: 1-5 in 10,000 (Uncommon).

1 clinical trial registered. Interventions under study include other interventions and gene therapy. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.

9 publications have been identified in PubMed for hyperlipoproteinemia type 3. Research spans Clinical Trial Publication (33%), Review / Meta-Analysis (22%), and Basic Science / Preclinical (22%).

Recent Publications

• Li Y (2026). [PMID: 41572203](https://pubmed.ncbi.nlm.nih.gov/41572203/). *BMC infectious diseases*. [Clinical Trial Publication]

• Li F (2025). [PMID: 40535644](https://pubmed.ncbi.nlm.nih.gov/40535644/). *American journal of translational research*. [Clinical Trial Publication]

• Zhang S (2025). [PMID: 39993083](https://pubmed.ncbi.nlm.nih.gov/39993083/). *Medicine*. [Review / Meta-Analysis]

• Emmert AS (2025). [PMID: 40147599](https://pubmed.ncbi.nlm.nih.gov/40147599/). *Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association*. [Review / Meta-Analysis]

• He Q (2025). [PMID: 39632416](https://pubmed.ncbi.nlm.nih.gov/39632416/). *Diabetes, obesity & metabolism*. [Clinical Trial Publication]

• Cooney EC (2024). [PMID: 38677354](https://pubmed.ncbi.nlm.nih.gov/38677354/). *Molecular phylogenetics and evolution*. [Basic Science / Preclinical]

• Son J (2024). [PMID: 38687597](https://pubmed.ncbi.nlm.nih.gov/38687597/). *Clinical cancer research : an official journal of the American Association for Cancer Research*. [Epidemiology / Natural History]

• Niimi M (2024). [PMID: 39087075](https://pubmed.ncbi.nlm.nih.gov/39087075/). *Frontiers in cardiovascular medicine*. [Basic Science / Preclinical]

• Maric GD (2024). [PMID: 39565794](https://pubmed.ncbi.nlm.nih.gov/39565794/). *PloS one*. [Epidemiology / Natural History]