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laryngotracheoesophageal cleft (LC) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

laryngotracheoesophageal cleft

MONDO:0016060

Also known as:LCLTECLarnygeotracheoesophageal cleft

Find Clinical TrialsTrials

Overview

A laryngo-tracheo-esophageal cleft (LC) is a congenital malformation characterized by an abnormal, posterior, sagittal communication between the larynx and the pharynx, possibly extending downward between the trachea and the esophagus.

Clinical Trials2 registered · 1 recruiting

Patient Orgs1 organizations · Laryngeal Cleft Network

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Laryngeal cleft; and common findings: Cyanosis, Laryngomalacia, Abnormality of the voice, and Hoarse cry and others. 13 total HPO annotations.

Organ System	Phenotype Count	Example Features
Lungs and breathing	3	Dyspnea, Recurrent respiratory infections, Neonatal respiratory distress

Diagnosis

Biomarker and diagnostic research for laryngotracheoesophageal cleft has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 always present feature, 11 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered, 1 recruiting. Interventions under study include medical devices and procedural interventions. Pipeline includes 2 NA. Research is primarily sponsored by academic and government institutions.

34 publications have been identified in PubMed for laryngotracheoesophageal cleft. Research spans Case Report / Case Series (32%), Clinical Trial Publication (29%), and Epidemiology / Natural History (24%).

Research Type	Count	% of Total
Patient case studies	11

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 11:13 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Patient Advocacy Groups

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Laryngeal Cleft NetworkPrimary Focus

USWebsite ↗

Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.

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Medical References

External Resources

Orphanet

European rare disease database

Orphanet:2004

GARD

Genetic and Rare Diseases Info Center

GARD:3188

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→How can I connect with Laryngeal Cleft Network and other patient organizations for support?

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Kisho

laryngotracheoesophageal cleft

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

laryngotracheoesophageal cleft

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications