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leukoencephalopathy with bilateral anterior temporal lobe cysts - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

leukoencephalopathy with bilateral anterior temporal lobe cysts

MONDO:0015348

Overview

Leukoencephalopathy with bilateral anterior temporal lobe cysts is a nonprogressive neurological disorder marked by intellectual deficit, spasticity and motor retardation associated with characteristic MRI findings of anterior bilateral temporal lobe cysts and multilobar leukoencephalopathy. So far, around 30 cases have been reported in the literature. Onset occurs in the first few months of life. Sensorineural deafness and microcephaly have also been reported. The etiology is unknown but an autosomal recessive mode of inheritance has been suggested.

ResearchLimited published research (3 articles)

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for leukoencephalopathy with bilateral anterior temporal lobe cysts.

3 publications have been identified in PubMed for leukoencephalopathy with bilateral anterior temporal lobe cysts. Research spans Case Report / Case Series (100%).

Recent Publications

V P (2025). [PMID: 39726909](https://pubmed.ncbi.nlm.nih.gov/39726909/). *Radiology case reports*. [Case Report / Case Series]
Retal H (2025). [PMID: 40255831](https://pubmed.ncbi.nlm.nih.gov/40255831/). *Cureus*. [Case Report / Case Series]
Algahtani H (2025). [PMID: 39481545](https://pubmed.ncbi.nlm.nih.gov/39481545/). *Encephalitis (Seoul, Korea)*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 9:43 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:139444

GARD

Genetic and Rare Diseases Info Center

GARD:19917

Questions for Your Care Team

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leukoencephalopathy with bilateral anterior temporal lobe cysts

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team