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Leukonychia totalis is a rare nail anomaly disorder characterized by complete white discoloration of the nails. Patients typically present white, chalky nails as an isolated finding, although other cutaneous or systemic manifestations could also be present.
Biomarker and diagnostic research for leukonychia totalis has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for leukonychia totalis.
6 publications have been identified in PubMed for leukonychia totalis. Research spans Case Report / Case Series (50%), Diagnostic / Biomarker (17%), and Clinical Trial Publication (17%).
Starace M (2026). [PMID: 41733801](https://pubmed.ncbi.nlm.nih.gov/41733801/). *Clin Drug Investig*. [Clinical Trial Publication]
Tan Y (2025). [PMID: 40766069](https://pubmed.ncbi.nlm.nih.gov/40766069/). *Front Med (Lausanne)*. [Case Report / Case Series]
Gutiérrez-Cerrajero C (2025). [PMID: 40423580](https://pubmed.ncbi.nlm.nih.gov/40423580/). *Acta Derm Venereol*. [Case Report / Case Series]
Gordon D (2024). [PMID: 39640961](https://pubmed.ncbi.nlm.nih.gov/39640961/). *Digit Health*. [Diagnostic / Biomarker]
Bhoi AK (2024). [PMID: 39108548](https://pubmed.ncbi.nlm.nih.gov/39108548/). *Skin Appendage Disord*. [Epidemiology / Natural History]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:53 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center