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Nail dysplasia is an idiopathic nail dystrophy, beginning in early childhood, and characterized by excessive longitudinal striations and loss of nail luster affecting all 20 nails.
Features include always present findings: Onychauxis, Nail dysplasia, and Onycholysis; and sometimes findings: Onychogryphosis. 5 total HPO annotations.
Organ System |
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Phenotype Count |
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Example Features |
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Skin | 1 | Nail dysplasia |
FZD6 encodes frizzled class receptor 6 (706 aa). Receptor for Wnt proteins. Highest expression in Cells Cultured fibroblasts (42.9 TPM) and Thyroid (32.7 TPM).
Nonsyndromic congenital nail disorder 1 is associated with mutations in the FZD6 gene on chromosome 8.
FZD6 is classified as a druggable target (Cell Surface, G Protein Coupled Receptor, and Kinase categories) with score 13.1.
Genetic testing for FZD6 is available. Testing is considered confirmatory for diagnosis.
Phenotype severity distribution: 3 always present features.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for nonsyndromic congenital nail disorder 1.
2 publications have been identified in PubMed for nonsyndromic congenital nail disorder 1. Research spans Review / Meta-Analysis (50%) and Basic Science / Preclinical (50%).
Wang Z (2025). [PMID: 39969530](https://pubmed.ncbi.nlm.nih.gov/39969530/). *The British journal of dermatology*. [Basic Science / Preclinical]
Cedirian S (2024). [PMID: 39386306](https://pubmed.ncbi.nlm.nih.gov/39386306/). *Skin appendage disorders*. [Review / Meta-Analysis]
Data assembled from 6 of 12 sources · Last updated Sep 20, 2026, 8:43 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center