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limbic encephalitis with LGI1 antibodies - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

limbic encephalitis with LGI1 antibodies

MONDO:0015592

Also known as:limbic encephalitis with leucine-rich glioma-inactivated 1 antibodies

Find Clinical TrialsTrials

Overview

Limbic encephalitis with LGI1 antibodies is a rare neuroimmunological disorder characterized by the onset of cognitive decline, psychiatric disturbances and seizures (distinctively faciobrachial dystonic seizures) in association with detection of LGI1 antibodies in serum or cerebrospinal fluid. Patients may present with confusion, hallucinations, vocalization, paranoia, tangentiality, aggressive outbursts and/or spatial disorientation, as well as obstinate hyponatremia. It is most often non-paraneoplastic, however comorbid tumors, such as small cell lung cancer and thymoma, have been reported.

Clinical Trials1 registered · 1 recruiting

Diagnosis

Biomarker and diagnostic research for limbic encephalitis with LGI1 antibodies has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered, 1 recruiting. Interventions under study include other interventions. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.

43 publications have been identified in PubMed for limbic encephalitis with LGI1 antibodies. Research spans Case Report / Case Series (60%), Epidemiology / Natural History (12%), and Review / Meta-Analysis (9%).

Research Type	Count	% of Total
Patient case studies	26

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 3:53 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:163908

GARD

Genetic and Rare Diseases Info Center

GARD:13406

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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limbic encephalitis with LGI1 antibodies

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications