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A rare neoplastic disease characterized by the presence of ten or more hepatocellular adenomas in a background of normal appearing hepatic parenchyma. The majority of reported cases are female. There is no association with steroid use. The condition is considered benign, although the risk of complications (such as malignant transformation or spontaneous rupture with intraperitoneal hemorrhage) is much higher than in isolated hepatic adenoma. Hepatocellular carcinoma develops in less than 10% of cases.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for liver adenomatosis.
8 publications have been identified in PubMed for liver adenomatosis. Research spans Case Report / Case Series (50%), Review / Meta-Analysis (38%), and Basic Science / Preclinical (13%).
Garbarine IC (2026). [PMID: 41680345](https://pubmed.ncbi.nlm.nih.gov/41680345/). *J Gastrointest Cancer*. [Review / Meta-Analysis]
Shreenath AP (2026). [PMID: 30020636](https://pubmed.ncbi.nlm.nih.gov/30020636/). *Unknown Journal*. [Review / Meta-Analysis]
Segatt PH (2025). [PMID: 40577161](https://pubmed.ncbi.nlm.nih.gov/40577161/). *Medicina (B Aires)*. [Review / Meta-Analysis]
Sjöholm Å (2025). [PMID: 41475867](https://pubmed.ncbi.nlm.nih.gov/41475867/). *BMJ Case Rep*. [Case Report / Case Series]
Alvarez J (2024). [PMID: 38862365](https://pubmed.ncbi.nlm.nih.gov/38862365/). *Transplant Proc*. [Case Report / Case Series]
Huang Y (2024). [PMID: 39262622](https://pubmed.ncbi.nlm.nih.gov/39262622/). *ACG Case Rep J*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 9:19 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Almunifi A (2024). [PMID: 39927057](https://pubmed.ncbi.nlm.nih.gov/39927057/). *J Pharm Bioallied Sci*. [Case Report / Case Series]
Faini AC (2024). [PMID: 39408812](https://pubmed.ncbi.nlm.nih.gov/39408812/). *Int J Mol Sci*. [Basic Science / Preclinical]