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loiasis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

loiasis

MONDO:0016566

Also known as:African eye wormLoa loa filariasis

Find Clinical TrialsTrials

Overview

Loiasis is a form of filariasis (see this term), caused by the parasitic worm Loa loa, endemic to the forest and savannah regions of Central and Western Africa. Loiasis may either be asymptomatic or manifest as a large, transient area of localized, non-erythematous subcutaneous edema (Calabar swellings), adult worm migration through the sub-conjunctiva (''African eye worm'') and pruritus. Generalized itching, hives, muscle pains, arthralgias, fatigue, and adult worms visibly migrating under the surface of the skin may be observed. Severe complications such as encephalopathy have been reported in highly infected individuals receiving ivermectin during mass drug administration programs for the control of onchocerciasis and lymphatic filariasis.

Clinical Trials3 registered · 2 recruiting

Diagnosis

Biomarker and diagnostic research for loiasis has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered, 2 recruiting. Interventions under study include drug therapy and biologic therapy. Pipeline includes 1 PHASE3, 1 PHASE2, 1 NA. Research is primarily sponsored by academic and government institutions.

58 publications have been identified in PubMed for loiasis. Research spans Epidemiology / Natural History (24%), Case Report / Case Series (21%), and Diagnostic / Biomarker (16%).

Research Type	Count	% of Total
Disease patterns and progression	14

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:52 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:2404

GARD

Genetic and Rare Diseases Info Center

GARD:3283

Questions for Your Care Team

→Are any of the 3 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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loiasis

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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