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Features include always present findings: Pedal edema; and common findings: Lymphedema.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 1 | Lymphedema |
TIE1 function has not been fully characterized.
Lymphatic malformation 11 is associated with mutations in the TIE1 gene on chromosome 1.
Genetic testing for TIE1 is available. Testing is considered confirmatory for diagnosis.
Biomarker and diagnostic research for lymphatic malformation 11 has been reported in the published literature.
Phenotype severity distribution: 1 always present feature, 1 common feature.
No clinical trials have been registered for lymphatic malformation 11.
106 publications have been identified in PubMed for lymphatic malformation 11. Research spans Case Report / Case Series (31%), Review / Meta-Analysis (19%), and Epidemiology / Natural History (17%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 32 | 31% |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 12:48 AM UTC
Online Mendelian Inheritance in Man
20 |
19% |
Disease patterns and progression | 18 | 17% |
Laboratory research | 10 | 10% |
Testing and diagnosis research | 9 | 9% |
New treatment approaches | 9 | 9% |
Clinical study results | 5 | 5% |
Khalayleh H (2026). [PMID: 41810342](https://pubmed.ncbi.nlm.nih.gov/41810342/). *World J Clin Oncol*. [Review / Meta-Analysis]
Zhu A (2026). [PMID: 41311114](https://pubmed.ncbi.nlm.nih.gov/41311114/). *Int J Gynaecol Obstet*. [Diagnostic / Biomarker]
Pakhathirathien P (2026). [PMID: 41224725](https://pubmed.ncbi.nlm.nih.gov/41224725/). *Hum Mol Genet*. [Gene Therapy / Novel Therapeutics]
Sasaki K (2026). [PMID: 41939643](https://pubmed.ncbi.nlm.nih.gov/41939643/). *Cureus*. [Case Report / Case Series]
Obereisenbuchner F (2026). [PMID: 42051780](https://pubmed.ncbi.nlm.nih.gov/42051780/). *Front Neurol*. [Epidemiology / Natural History]
Pickles MW (2026). [PMID: 41663675](https://pubmed.ncbi.nlm.nih.gov/41663675/). *Pituitary*. [Epidemiology / Natural History]
Han WT (2026). [PMID: 41834198](https://pubmed.ncbi.nlm.nih.gov/41834198/). *Zhonghua Er Ke Za Zhi*. [Gene Therapy / Novel Therapeutics]
Sopchokchai I (2026). [PMID: 41974057](https://pubmed.ncbi.nlm.nih.gov/41974057/). *J Neurosurg Case Lessons*. [Case Report / Case Series]
Gada J (2026). [PMID: 41641161](https://pubmed.ncbi.nlm.nih.gov/41641161/). *JHLT Open*. [Epidemiology / Natural History]
González-Hernández S (2026). [PMID: 41480750](https://pubmed.ncbi.nlm.nih.gov/41480750/). *JCI Insight*. [Basic Science / Preclinical]