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Lymphomatoid papulosis (LyP) is a rare cutaneous condition characterized by chronic, recurrent, and self-regressing papulonodular skin eruptions. It belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders, along with primary cutaneous anaplastic large cell lymphoma (primary C-ALCL) with which it shares overlapping clinical and histopathologic features.
Biomarker and diagnostic research for lymphomatoid papulosis has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
5 clinical trials registered, 3 recruiting. Interventions under study include drug therapy, other interventions, and biologic therapy. Pipeline includes 2 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06207812](https://clinicaltrials.gov/study/NCT06207812) |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 5:06 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Long-term Outcomes Associated With Juvenile-onset Mycosis Fungoides and Lymphomatoid Papulosis |
— |
M.D. Anderson Cancer Center |
RECRUITING |
[NCT03602157](https://clinicaltrials.gov/study/NCT03602157) | Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL | PHASE1 | UNC Lineberger Comprehensive Cancer Center | ACTIVE_NOT_RECRUITING |
[NCT02840747](https://clinicaltrials.gov/study/NCT02840747) | Tissue Repository: CTCL Collection Protocol | — | Columbia University | RECRUITING |
[NCT01352520](https://clinicaltrials.gov/study/NCT01352520) | SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP) | PHASE2 | M.D. Anderson Cancer Center | ACTIVE_NOT_RECRUITING |
[NCT03587844](https://clinicaltrials.gov/study/NCT03587844) | Dosing of Brentuximab Vedotin for Mycosis Fungoides, Sezary Syndrome Patients | PHASE2 | Memorial Sloan Kettering Cancer Center | RECRUITING |
65 publications have been identified in PubMed for lymphomatoid papulosis. Research spans Case Report / Case Series (49%), Review / Meta-Analysis (20%), and Epidemiology / Natural History (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 32 | 49% |
Research summaries | 13 | 20% |
Disease patterns and progression | 9 | 14% |
New treatment approaches | 4 | 6% |
Laboratory research | 3 | 5% |
Other research | 2 | 3% |
Testing and diagnosis research | 1 | 2% |
Clinical study results | 1 | 2% |
Bowers JT (2026). [PMID: 42192920](https://pubmed.ncbi.nlm.nih.gov/42192920/). *Cancers (Basel)*. [Review / Meta-Analysis]
Daniels P (2026). [PMID: 41909238](https://pubmed.ncbi.nlm.nih.gov/41909238/). *JAAD Case Rep*. [Case Report / Case Series]
Anadón Valero H (2026). [PMID: 41962207](https://pubmed.ncbi.nlm.nih.gov/41962207/). *Rev Esp Patol*. [Case Report / Case Series]
Junkins-Hopkins JM (2026). [PMID: 41951332](https://pubmed.ncbi.nlm.nih.gov/41951332/). *Dermatol Clin*. [Review / Meta-Analysis]
Rapparini L (2026). [PMID: 42166117](https://pubmed.ncbi.nlm.nih.gov/42166117/). *Ital J Dermatol Venerol*. [Review / Meta-Analysis]
Martins KH (2026). [PMID: 41636467](https://pubmed.ncbi.nlm.nih.gov/41636467/). *The American Journal of dermatopathology*. [Gene Therapy / Novel Therapeutics]
Torre-Castro J (2026). [PMID: 41601235](https://pubmed.ncbi.nlm.nih.gov/41601235/). *Leukemia & lymphoma*. [Case Report / Case Series]
Alexopoulos A (2026). [PMID: 41815622](https://pubmed.ncbi.nlm.nih.gov/41815622/). *Cureus*. [Case Report / Case Series]
Meledathu S (2026). [PMID: 42085604](https://pubmed.ncbi.nlm.nih.gov/42085604/). *Blood Adv*. [Basic Science / Preclinical]
Weiner D (2026). [PMID: 41387293](https://pubmed.ncbi.nlm.nih.gov/41387293/). *Journal of cutaneous pathology*. [Case Report / Case Series]