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Malaria — NIH Grants & Funding

Active and recent NIH-funded research on Malaria. Data from NIH RePORTER, last 36 months.

MONDO:0005136

NIH-funded research on Malaria

258

active grants

110

institutions

287

researchers

new in last 12 mo.

$316.4M in NIH funding over the last 36 months. Data from NIH RePORTER.

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Basic Science(134)

Basic ScienceZIACompleted

Malaria immunology

Pierce, Susan·NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

$5,503,594 (FY2025)

Malaria — NIH Grants & Funding

Basic Science(134)

Malaria immunology

Optimizing malaria transmission-blocking vaccines with improved platforms

Human monoclonal antibodies targeting infectious pathogens

Mosquito Immune Responses and Malaria Transmission

Nitric Oxide and Endothelial Function in Patients with Malaria

Vaccines to Interrupt Malaria Transmission: Discovery and Assays

Malaria Drug Resistance and Disease Virulence

Assays to Support Development of Malaria Transmission Blocking Vaccines

Cellular and Molecular Physiology of Bloodstream Malaria Parasites

Malaria Parasite Genomics, Development, Drug Resistance, Pathogenesis, and Host-parasite Interaction

Translational(57)

SBIR Topic 109: Development of Monoclonal Antibody- Mediated Interventions to Combat Malaria

Defining the resistome in P. falciparum: evolution and mechanism

A GLYCOLIPID ADJUVANT 7DW8-5 FOR MALARIA VACCINES

Impact of gene-drive systems for population modification on malaria vector mosquitoes

Expanding the breadth, magnitude, and durability of PfSPZ vaccines by creating multi-strain vaccines, designer hybrid and genetically altered parasite vaccines and use of a unique adjuvant.

Recombinant Outer Membrane Vesicles as a Novel Adjuvant for a Malaria Vaccine

A glycolipid adjuvant to promote dose sparing, accelerate immunization schedules and extend durability of high-level protection with an attenuated, live sporozoite malaria vaccine

Defining the immunogenic landscape of early mosquito-stage P. falciparum to accelerate malaria transmission-blocking vaccine discovery

Leveraging PfCRT Structure to Discern Function and Predict Emergence of Drug-Resistant Malaria

Potent Antibody Protection Against P. falciparum and P. vivax Malaria

Clinical(45)

Vaccines to Interrupt Malaria Transmission: Clinical Development

Malaria Pathogenesis in young children and vaccine discovery

Improving Neonatal health Through Rapid malaria testing in Early Pregnancy with high-sensitivity Diagnostics (INTREPiD)

Integrating human and non-human primate data to understand the acquisition of pre-erythrocytic immunity in the face of previous malaria exposure

Pre-erythrocytic malaria vaccines: Discovery and Clinical Development

Mapping Drug Resistance Genes in Plasmodium falciparum

Accelerating discovery of an efficacious Plasmodium vivax multivalent multi-stage vaccine

Mechanisms of innate immune dysfunction in SIV/malaria co-infection in pregnancy

Examining the mechanisms and optimization of malaria chemoprevention strategies to improve birth outcomes in Africa

Collective Responses to Malaria Vaccination

Epi / Nat. History(47)

Long-term health and socioeconomic impact of interventions targeting low-density malaria infection (LMI) among children in Tanzaniav

The changing landscape of human and zoonotic malaria in Southeast Asia

Innate-adaptive immune bridging in gravidity-dependent immunity against placental malaria: a multi-omics approach

Mosquito SAMSP1 and SAMSP2 influence the initial stage of Plasmodium infection of mice

Malaria across borders: Measuring imported infections and contributions to local transmission in Uganda and Zimbabwe

Accelerating malaria prevention through enhanced analysis of transmission and RTS,S vaccination in Malawi

Harnessing Innovation to Transform Malaria Surveillance into Key Interventions Across Transmission Settings in Zambia

Importation and transmission of malaria in Zanzibar: a case study for elimination

West-Central Africa EMERGENTS International Center of Excellence in Malaria Research (ICEMR)

Plasmodium and Anopheles midgut interactive proteins influence malaria transmission

Gene/Cell Therapy(1)

Development of next-generation gene drive technologies for Anopheles population engineering

Biomarker / Dx(7)

CRISPR-based Assay for Portable Tropical Infection Diagnosis

Progressing PfSPZ vaccines for malaria to licensure and commercialization

Automated Mobile Microscopy for Malaria Diagnosis and surveillance in Uganda

Precise field-friendly methods for quantification of antimalarial drugs in dried blood spots

Parasite variant surface antigen expression and immune gaps in severe malaria

Identifying functional antibody responses that protect against malaria in children

NOVEL DIAGNOSTIC BIOMARKERS DISCOVERY AND VALIDATION FOR MALARIA

Medical Device(2)

An instrument-free malaria diagnostic

Phase II STTR development of an intranasal/oral Spirulina-based PfCSP malaria vaccine.

Other(16)

Mechanisms of naturally-acquired immunity to malaria and clinical trials of anti-malaria monoclonal antibodies

Type-I Interferons drive cell-autonomous immunity to malaria

Optimization of novel phenotypic screening hits for treatment of Malaria

Global Research Endeavors to Advance Treatment of Neurological Disorders in Africa (GREAT Neurology)

Defining conserved epitopes on polymorphic malaria antigens

In vitro modeling of blood brain barrier dysfunction on a chip to elucidate the pathogenesis of cerebral malaria

Malaria and Mosquito/Tick-borne Diseases

Mali-Guinea Research Leadership Training Program for Sustainable control and elimination of Malaria and Neglected tropical diseases

Training and Research on Severe Malarial Anemia

Building an India-Africa Network to Support Research and Control of Urban Malaria Transmission