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A male infertility disorder characterized by defective sperm morphology, specifically the absence of the sperm head which prevents natural or assisted fertilization.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for male infertility due to acephalic spermatozoa.
20 publications have been identified in PubMed for male infertility due to acephalic spermatozoa. Research spans Basic Science / Preclinical (40%), Review / Meta-Analysis (20%), and Case Report / Case Series (15%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 8 | 40% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 3:14 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries
4 |
20% |
Patient case studies | 3 | 15% |
New treatment approaches | 2 | 10% |
Other research | 1 | 5% |
Clinical study results | 1 | 5% |
Disease patterns and progression | 1 | 5% |
Moecking J (2026). [PMID: 41855266](https://pubmed.ncbi.nlm.nih.gov/41855266/). *Proc Natl Acad Sci U S A*. [Basic Science / Preclinical]
Kluczynski DF (2026). [PMID: 41489787](https://pubmed.ncbi.nlm.nih.gov/41489787/). *J Assist Reprod Genet*. [Review / Meta-Analysis]
Tian Y (2026). [PMID: 41499646](https://pubmed.ncbi.nlm.nih.gov/41499646/). *Clin Genet*. [Case Report / Case Series]
Yang X (2025). [PMID: 41004021](https://pubmed.ncbi.nlm.nih.gov/41004021/). *J Assist Reprod Genet*. [Clinical Trial Publication]
Qiu Y (2025). [PMID: 39292630](https://pubmed.ncbi.nlm.nih.gov/39292630/). *Biol Reprod*. [Basic Science / Preclinical]
Alinia S (2025). [PMID: 40740627](https://pubmed.ncbi.nlm.nih.gov/40740627/). *J Hum Reprod Sci*. [Epidemiology / Natural History]
Rojas-Barón L (2025). [PMID: 40318165](https://pubmed.ncbi.nlm.nih.gov/40318165/). *FEBS J*. [Basic Science / Preclinical]
Li K (2025). [PMID: 39953708](https://pubmed.ncbi.nlm.nih.gov/39953708/). *Hum Reprod Update*. [Review / Meta-Analysis]
Liu C (2025). [PMID: 41462896](https://pubmed.ncbi.nlm.nih.gov/41462896/). *Biomedicines*. [Gene Therapy / Novel Therapeutics]
Hosseini SH (2025). [PMID: 40977202](https://pubmed.ncbi.nlm.nih.gov/40977202/). *Reprod Fertil Dev*. [Case Report / Case Series]