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An aggressive malignant mesothelioma that arises from the peritoneum. Patients usually present with abdominal pain and ascites.
Features include very common findings: Ascites, Abdominal pain, Peritonitis, and Neoplasm and others; and common findings: Weight loss. 10 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Digestive system | 3 | Ascites, Abdominal pain, Abdominal distention |
Biomarker and diagnostic research for malignant peritoneal mesothelioma has been reported in the published literature.
Phenotype severity distribution: 5 very common features, 1 common feature.
Estimated prevalence: 1-9 in 100,000 (Uncommon).
15 clinical trials registered, 10 recruiting. Interventions under study include drug therapy, biologic therapy, other interventions, and procedural interventions. Pipeline includes 5 PHASE2, 7 PHASE1, 1 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06885697](https://clinicaltrials.gov/study/NCT06885697) |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 6:54 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
1 |
Weight loss |
Blood and immune system | 1 | Blood clotting problems (abnormality of coagulation) |
Lungs and breathing | 1 | Dyspnea |
Neoplasm | 1 | Neoplasm |
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma |
PHASE1 |
National Cancer Institute (NCI) |
RECRUITING |
[NCT06581549](https://clinicaltrials.gov/study/NCT06581549) | Immune Microenvironment and Gene Expression Profiling in Mesothelioma | — | Istituto Oncologico Veneto IRCCS | RECRUITING |
[NCT06756035](https://clinicaltrials.gov/study/NCT06756035) | CT-95 in Advanced Cancers Associated With Mesothelin Expression | PHASE1 | Context Therapeutics Inc. | RECRUITING |
[NCT06057935](https://clinicaltrials.gov/study/NCT06057935) | A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma | PHASE2 | Memorial Sloan Kettering Cancer Center | RECRUITING |
[NCT01617382](https://clinicaltrials.gov/study/NCT01617382) | Register With Patients in Which Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) Was Performed | — | Universitaire Ziekenhuizen KU Leuven | RECRUITING |
93 publications have been identified in PubMed for malignant peritoneal mesothelioma. Research spans Case Report / Case Series (48%), Clinical Trial Publication (20%), and Diagnostic / Biomarker (8%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 45 | 48% |
Clinical study results | 19 | 20% |
Testing and diagnosis research | 7 | 8% |
New treatment approaches | 7 | 8% |
Research summaries | 5 | 5% |
Laboratory research | 5 | 5% |
Disease patterns and progression | 5 | 5% |
Zhao Q (2026). [PMID: 42154413](https://pubmed.ncbi.nlm.nih.gov/42154413/). *Ir J Med Sci*. [Review / Meta-Analysis]
Gong Q (2026). [PMID: 41711168](https://pubmed.ncbi.nlm.nih.gov/41711168/). *Genes, chromosomes & cancer*. [Basic Science / Preclinical]
Doldi V (2026). [PMID: 42169033](https://pubmed.ncbi.nlm.nih.gov/42169033/). *J Transl Med*. [Diagnostic / Biomarker]
Liang XL (2026). [PMID: 40891423](https://pubmed.ncbi.nlm.nih.gov/40891423/). *International journal of cancer*. [Case Report / Case Series]
Noiret B (2026). [PMID: 41785549](https://pubmed.ncbi.nlm.nih.gov/41785549/). *European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology*. [Epidemiology / Natural History]
Urbano-Ruiz A (2026). [PMID: 41628072](https://pubmed.ncbi.nlm.nih.gov/41628072/). *The American journal of case reports*. [Case Report / Case Series]
Gibson J (2026). [PMID: 41832298](https://pubmed.ncbi.nlm.nih.gov/41832298/). *British journal of cancer*. [Case Report / Case Series]
Andresen JR (2026). [PMID: 41523226](https://pubmed.ncbi.nlm.nih.gov/41523226/). *Journal of surgical case reports*. [Case Report / Case Series]
Kitajima K (2026). [PMID: 41863665](https://pubmed.ncbi.nlm.nih.gov/41863665/). *Jpn J Radiol*. [Diagnostic / Biomarker]
Castagna A (2026). [PMID: 42118694](https://pubmed.ncbi.nlm.nih.gov/42118694/). *Dig Surg*. [Review / Meta-Analysis]
AI-curated news mentioning malignant peritoneal mesothelioma
Updated Jun 1, 2026
A new study explores conditional survival patterns and individualized prognostic predictions for malignant peritoneal mesothelioma. This research could enhance patient management and treatment strategies for this rare cancer.