Mayer-Rokitansky-Küster-Hauser syndrome type 2

Mayer-Rokitansky-Küster-Hauser syndrome type 2 is a rare condition present from birth in which people do not develop a uterus and the upper two-thirds of the vagina. It is called a congenital condition because these differences occur during development. The condition is also known as MURCS, which stands for Mullerian duct aplasia, Renal dysplasia, and Cervical Somite anomalies, highlighting that other body systems like the kidneys and spine may also be affected. People with this condition may learn about it through investigations related to reproductive health or other symptoms connected to associated malformations. While the absence of certain reproductive structures is the primary feature, additional anomalies affecting organs such as the kidneys, spine, and, less commonly, the ears or heart, can also be part of the clinical picture.

The main symptom of this condition is the congenital absence of the uterus and the upper two-thirds of the vagina. Many people with this condition also have other malformations such as renal (kidney) issues or vertebral (spine) anomalies. In some instances, less commonly, issues with hearing or the heart may be present.

This condition occurs from birth and is considered congenital. The specific causes are not well understood and there are no known genetic mutations clearly linked to this condition at this time.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.