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A lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma.
Biomarker and diagnostic research for mediastinal malignant lymphoma has been reported in the published literature.
5 clinical trials registered, 2 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 1 PHASE4, 1 PHASE3, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT03969693](https://clinicaltrials.gov/study/NCT03969693) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:50 AM UTC
Lymphoma Patients Undergoing Mediastinal Radiotherapy in the Era of Modern Chemoradiation |
— |
Chang Gung Memorial Hospital |
NOT_YET_RECRUITING |
[NCT04613388](https://clinicaltrials.gov/study/NCT04613388) | Registry Study of Proton Radiotherapy in Lymphoma | — | University Hospital Heidelberg | RECRUITING |
[NCT04787263](https://clinicaltrials.gov/study/NCT04787263) | CD19-CAR_Lenti T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ ALL and DLBCL or PML | PHASE1 | Bambino Gesù Hospital and Research Institute | ACTIVE_NOT_RECRUITING |
[NCT05518383](https://clinicaltrials.gov/study/NCT05518383) | B-cell Mature Non-Hodgkin's Lymphoma Treatment Protocol in Children and Adolescents 2021 | PHASE4 | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | RECRUITING |
[NCT06188676](https://clinicaltrials.gov/study/NCT06188676) | Multicenter Study of Safety and Efficacy Nivolumab at the Fixed Dose 40 mg (Nivo40) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed PMBL | PHASE3 | National Research Center for Hematology, Russia | UNKNOWN |
154 publications have been identified in PubMed for mediastinal malignant lymphoma. Research spans Case Report / Case Series (50%), Review / Meta-Analysis (14%), and Clinical Trial Publication (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 77 | 50% |
Research summaries | 21 | 14% |
Clinical study results | 21 | 14% |
Testing and diagnosis research | 14 | 9% |
Laboratory research | 11 | 7% |
Disease patterns and progression | 6 | 4% |
Other research | 3 | 2% |
New treatment approaches | 1 | 1% |
Farooq S (2026). [PMID: 41982616](https://pubmed.ncbi.nlm.nih.gov/41982616/). *Mediastinum*. [Review / Meta-Analysis]
Utomo VP (2026). [PMID: 41978302](https://pubmed.ncbi.nlm.nih.gov/41978302/). *Acta Med Indones*. [Case Report / Case Series]
Wang WJ (2026). [PMID: 42248336](https://pubmed.ncbi.nlm.nih.gov/42248336/). *Hum Pathol*. [Review / Meta-Analysis]
Wang H (2026). [PMID: 41054254](https://pubmed.ncbi.nlm.nih.gov/41054254/). *J Thorac Imaging*. [Diagnostic / Biomarker]
Qin J (2026). [PMID: 41389632](https://pubmed.ncbi.nlm.nih.gov/41389632/). *Pathology, research and practice*. [Diagnostic / Biomarker]
Ha JH (2026). [PMID: 42021110](https://pubmed.ncbi.nlm.nih.gov/42021110/). *J Vet Med Sci*. [Case Report / Case Series]
Nishiyama K (2026). [PMID: 41743898](https://pubmed.ncbi.nlm.nih.gov/41743898/). *Respirology case reports*. [Review / Meta-Analysis]
Imran S (2026). [PMID: 41175477](https://pubmed.ncbi.nlm.nih.gov/41175477/). *J Am Vet Med Assoc*. [Case Report / Case Series]
Wei P (2026). [PMID: 42265636](https://pubmed.ncbi.nlm.nih.gov/42265636/). *BMC Pregnancy Childbirth*. [Case Report / Case Series]
Mousavi NS (2026). [PMID: 42006532](https://pubmed.ncbi.nlm.nih.gov/42006532/). *Clin Case Rep*. [Case Report / Case Series]
AI-curated news mentioning mediastinal malignant lymphoma
Updated May 20, 2026
A recent study highlights methotrexate-induced myelopathy as a significant mimic of relapsed malignant lymphoma, complicating diagnosis. This discovery emphasizes the need for careful evaluation in patients undergoing methotrexate treatment.