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Microlissencephaly describes a heterogenous group of a rare cortical malformations characterized by lissencephaly in combination with severe congenital microcephaly, presenting with spasticity, severe developmental delay, and seizures and with survival varying from days to years.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for microlissencephaly.
4 publications have been identified in PubMed for microlissencephaly. Research spans Review / Meta-Analysis (25%), Case Report / Case Series (25%), and Basic Science / Preclinical (25%).
Abdel-Salam GMH (2026). [PMID: 41436176](https://pubmed.ncbi.nlm.nih.gov/41436176/). *Journal of medical genetics*. [Epidemiology / Natural History]
Yalçın HY (2025). [PMID: 39911170](https://pubmed.ncbi.nlm.nih.gov/39911170/). *Molecular syndromology*. [Case Report / Case Series]
Dionne O (2025). [PMID: 39222411](https://pubmed.ncbi.nlm.nih.gov/39222411/). *Brain : a journal of neurology*. [Review / Meta-Analysis]
Doobin DJ (2024). [PMID: 39167527](https://pubmed.ncbi.nlm.nih.gov/39167527/). *Molecular biology of the cell*. [Basic Science / Preclinical]
Data assembled from 3 of 12 sources · Last updated Sep 17, 2026, 9:16 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center