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Moderately severe hemophilia A is a form of hemophilia A characterized by factor VIII deficiency leading to abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction.
Biomarker and diagnostic research for moderately severe hemophilia A has been reported in the published literature.
2 clinical trials registered, 2 recruiting. Interventions under study include drug therapy and biologic therapy. Pipeline includes 2 PHASE1. Research is primarily industry-sponsored.
132 publications have been identified in PubMed for moderately severe hemophilia A. Research spans Epidemiology / Natural History (30%), Clinical Trial Publication (22%), and Review / Meta-Analysis (15%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 40 |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:55 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Clinical study results | 29 | 22% |
Research summaries | 20 | 15% |
Laboratory research | 19 | 14% |
Patient case studies | 9 | 7% |
Testing and diagnosis research | 7 | 5% |
New treatment approaches | 7 | 5% |
Other research | 1 | 1% |
Matino D (2026). [PMID: 42100157](https://pubmed.ncbi.nlm.nih.gov/42100157/). *Ther Adv Hematol*. [Review / Meta-Analysis]
Nogami K (2026). [PMID: 41643195](https://pubmed.ncbi.nlm.nih.gov/41643195/). *Blood*. [Clinical Trial Publication]
Marco-Rico A (2026). [PMID: 41883838](https://pubmed.ncbi.nlm.nih.gov/41883838/). *J Blood Med*. [Basic Science / Preclinical]
Warren BB (2026). [PMID: 41979075](https://pubmed.ncbi.nlm.nih.gov/41979075/). *Haemophilia*. [Basic Science / Preclinical]
Riboldi L (2026). [PMID: 41809524](https://pubmed.ncbi.nlm.nih.gov/41809524/). *Front Pediatr*. [Case Report / Case Series]
Komvilaisak P (2026). [PMID: 41711156](https://pubmed.ncbi.nlm.nih.gov/41711156/). *Haemophilia*. [Epidemiology / Natural History]
Wheeler AP (2026). [PMID: 41906926](https://pubmed.ncbi.nlm.nih.gov/41906926/). *Haemophilia*. [Epidemiology / Natural History]
Patel P (2026). [PMID: 42221916](https://pubmed.ncbi.nlm.nih.gov/42221916/). *Ther Adv Hematol*. [Other]
Olivieri M (2026). [PMID: 42158717](https://pubmed.ncbi.nlm.nih.gov/42158717/). *Transfus Med Hemother*. [Review / Meta-Analysis]
Mohammed BM (2026). [PMID: 42202884](https://pubmed.ncbi.nlm.nih.gov/42202884/). *J Thromb Haemost*. [Basic Science / Preclinical]