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symptomatic form of hemophilia A in female carriers - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

symptomatic form of hemophilia A in female carriers

MONDO:0015787

Overview

A form of hemophilia A that manifests in some women with mutations in the F8 gene (Xq28), encoding coagulation factor VIII.

ResearchLimited published research (2 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Bruising susceptibility and Reduced factor VIII activity; and common findings: Menorrhagia, Epistaxis, Abnormal bleeding tendency (abnormal bleeding), and Prolonged bleeding after surgery and others. 12 total HPO annotations.

Organ System	Phenotype Count	Example Features
Blood and immune system	4	Abnormal bleeding tendency (abnormal bleeding), Prolonged bleeding after surgery, Prolonged bleeding after dental extraction

Prognosis

Phenotype severity distribution: 2 very common features, 7 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for symptomatic form of hemophilia A in female carriers.

2 publications have been identified in PubMed for symptomatic form of hemophilia A in female carriers. Research spans Clinical Trial Publication (50%) and Epidemiology / Natural History (50%).

Recent Publications

Krumb E (2024). [PMID: 39167764](https://pubmed.ncbi.nlm.nih.gov/39167764/). *Blood advances*. [Epidemiology / Natural History]
Bakhsh E (2024). [PMID: 38792643](https://pubmed.ncbi.nlm.nih.gov/38792643/). *Life (Basel, Switzerland)*. [Clinical Trial Publication]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 9:58 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:177926

GARD

Genetic and Rare Diseases Info Center

GARD:17076

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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symptomatic form of hemophilia A in female carriers

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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