Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome is a rare condition that brings together features of Moebius syndrome and additional issues affecting the nerves and hormonal regulation. Moebius syndrome is known for congenital facial palsy and problems with eye movement, particularly the ability to move the eyes outward. In this condition, these features are found together with peripheral axonal neuropathy, which affects the nerves, and hypogonadotropic hypogonadism, which impacts hormonal signals necessary for normal sexual development.

People with this condition may show signs of facial muscle weakness, which can include a lack of facial expressions, and difficulty with eye movement due to impaired ocular abduction. They may also experience symptoms related to peripheral nerve issues and reduced function of the hormones that promote sexual development and health.

This syndrome is associated with congenital Moebius syndrome combined with peripheral axonal neuropathy and hypogonadotropic hypogonadism. However, detailed information on the exact causes, genetics, and risk factors is limited for this condition.