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multicentric Castleman disease - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

multicentric Castleman disease

MONDO:0019754

Also known as:HHV-8-associated multicentric Castleman diseaseHuman herpesvirus-8-associated multicentric Castleman diseaseMCD

Find Clinical TrialsTrials

Overview

Multicentric castleman disease (MCD) is an aggressive form of Castleman disease that mostly results from human herpesvirus 8 (HHV8) infection. It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein.

Clinical Trials8 registered · 4 recruiting

Patient Orgs1 organizations · Castleman Disease Collaborative Network

Diagnosis

Biomarker and diagnostic research for multicentric Castleman disease has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

8 clinical trials registered, 4 recruiting. Interventions under study include drug therapy, other interventions, and procedural interventions. Pipeline includes 4 PHASE2. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT00006518](https://clinicaltrials.gov/study/NCT00006518)

Data assembled from 4 of 12 sources · Last updated Nov 3, 2026, 2:35 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Patient Advocacy Groups

View all PAGs →

Castleman Disease Collaborative NetworkPrimary Focus

USWebsite ↗

Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.

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Medical References

External Resources

Orphanet

European rare disease database

Orphanet:570438 Orphanet:93686

GARD

Genetic and Rare Diseases Info Center

GARD:22310

Questions for Your Care Team

→Are any of the 8 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→How can I connect with Castleman Disease Collaborative Network and other patient organizations for support?

← Back to All Diseases

Research Type	Count	% of Total
Patient case studies	106	49%
Research summaries	27	12%
Laboratory research	26	12%
Disease patterns and progression	19	9%
Testing and diagnosis research	16	7%
Clinical study results	15	7%
Other research	6	3%
New treatment approaches	3	1%

Kisho

multicentric Castleman disease

Overview

Diagnosis

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

HHV8-associated multicentric Castleman disease with Kaposi sarcoma in an immunocompetent patient: a case report and review of the literature.

Contrast-Enhanced Ultrasound in the Diagnosis of Parotid Gland Castleman Disease in a Child.

Morbidity burden and healthcare costs in idiopathic multicentric Castleman disease (BURDEN-iMCD): a retrospective population-level matched cohort analysis.

multicentric Castleman disease

Overview

Diagnosis

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

HHV8-associated multicentric Castleman disease with Kaposi sarcoma in an immunocompetent patient: a case report and review of the literature.

Contrast-Enhanced Ultrasound in the Diagnosis of Parotid Gland Castleman Disease in a Child.

Morbidity burden and healthcare costs in idiopathic multicentric Castleman disease (BURDEN-iMCD): a retrospective population-level matched cohort analysis.