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The loss of muscle tissue due to inactivity or disease.
Biomarker and diagnostic research for muscular atrophy has been reported in the published literature.
139 clinical trials registered, 59 recruiting. Interventions under study include other interventions, drug therapy, medical devices, and biologic therapy. Pipeline includes 5 PHASE4, 11 PHASE3, 9 PHASE2. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05768048](https://clinicaltrials.gov/study/NCT05768048) |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:58 PM UTC
Long Term Trajectories of SMA Patients Receiving or Not Disease-modifying Treatments |
— |
Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
RECRUITING |
[NCT07265232](https://clinicaltrials.gov/study/NCT07265232) | Real World Clinical Effectiveness & Safety of Vesemnogene Lantuparvovec for Spinal Muscular Atrophy (SMA) in Low-middle Income Countries (LMIC). | PHASE3 | Lantu Biopharma | RECRUITING |
[NCT05824169](https://clinicaltrials.gov/study/NCT05824169) | Evaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal Muscular Atrophy (SMA) Type 1 Patients | PHASE1 | GeneCradle Inc | RECRUITING |
[NCT07178353](https://clinicaltrials.gov/study/NCT07178353) | Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults | NA | Queen's University | RECRUITING |
[NCT07286565](https://clinicaltrials.gov/study/NCT07286565) | Active NBS Study: Decentralised Monitoring Motor Development in Children With Duchenne Muscular Dystrophy or Spinal Muscular Atrophy Identified by Newborn Screening | NA | Centre Hospitalier Universitaire de Liege | RECRUITING |
500 publications have been identified in PubMed for muscular atrophy. Research spans Review / Meta-Analysis (33%), Basic Science / Preclinical (28%), and Epidemiology / Natural History (16%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 165 | 33% |
Laboratory research | 141 | 28% |
Disease patterns and progression | 81 | 16% |
New treatment approaches | 35 | 7% |
Clinical study results | 32 | 6% |
Testing and diagnosis research | 31 | 6% |
Patient case studies | 13 | 3% |
Other research | 2 | 0% |
Chen Y (2026). [PMID: 42010894](https://pubmed.ncbi.nlm.nih.gov/42010894/). *Mediators Inflamm*. [Review / Meta-Analysis]
Chung HS (2026). [PMID: 41531287](https://pubmed.ncbi.nlm.nih.gov/41531287/). *Diabetes Metab J*. [Review / Meta-Analysis]
Walter MC (2026). [PMID: 40938644](https://pubmed.ncbi.nlm.nih.gov/40938644/). *J Neuromuscul Dis*. [Review / Meta-Analysis]
Jia L (2026). [PMID: 42166975](https://pubmed.ncbi.nlm.nih.gov/42166975/). *Phytomedicine*. [Basic Science / Preclinical]
Patel R (2026). [PMID: 41791198](https://pubmed.ncbi.nlm.nih.gov/41791198/). *Pediatr Neurol*. [Review / Meta-Analysis]
Menzies C (2026). [PMID: 41707658](https://pubmed.ncbi.nlm.nih.gov/41707658/). *J Cachexia Sarcopenia Muscle*. [Review / Meta-Analysis]
de Sousa MV (2026). [PMID: 41691131](https://pubmed.ncbi.nlm.nih.gov/41691131/). *Sports Med*. [Review / Meta-Analysis]
Varamini B (2026). [PMID: 41899733](https://pubmed.ncbi.nlm.nih.gov/41899733/). *Int J Environ Res Public Health*. [Review / Meta-Analysis]
Jiawei C (2026). [PMID: 41858037](https://pubmed.ncbi.nlm.nih.gov/41858037/). *Med Sci Monit*. [Clinical Trial Publication]
Stephan A (2026). [PMID: 41638874](https://pubmed.ncbi.nlm.nih.gov/41638874/). *J Cachexia Sarcopenia Muscle*. [Basic Science / Preclinical]