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Muscular pain in numerous body regions that can be reproduced by pressure on trigger points, localized hardenings in skeletal muscle tissue. Pain is referred to a location distant from the trigger points. A prime example is the temporomandibular joint dysfunction syndrome.
Biomarker and diagnostic research for myofascial pain syndrome has been reported in the published literature.
57 clinical trials registered, 23 recruiting. Interventions under study include other interventions, drug therapy, procedural interventions, and medical devices. Pipeline includes 2 PHASE4, 1 PHASE3, 2 PHASE2. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06746922](https://clinicaltrials.gov/study/NCT06746922) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:32 PM UTC
Intermittent Theta Burst Stimulation in Fibromyalgia Syndrome |
NA |
Izmir Katip Celebi University |
RECRUITING |
[NCT06892041](https://clinicaltrials.gov/study/NCT06892041) | Diffusion MRI for Quantitative Assessment of Myofascial Pain | — | Weill Medical College of Cornell University | RECRUITING |
[NCT07119255](https://clinicaltrials.gov/study/NCT07119255) | Effectiveness of PRP Pharmacopuncture for Chronic Neck Pain in Cervical Myofascial Syndrome of the Upper Trapezius | NA | Universitas Indonesia | RECRUITING |
[NCT07171320](https://clinicaltrials.gov/study/NCT07171320) | The Efficacy and Safety of Pregabalin Combined With Desvenlafaxine in Patients With Fibromyalgia | NA | Beijing Tiantan Hospital | RECRUITING |
[NCT07494162](https://clinicaltrials.gov/study/NCT07494162) | Imaging Metabolic and Perfusion Changes in Acupuncture Therapy for Myofascial Pain Syndrome | NA | University of California, Davis | RECRUITING |
205 publications have been identified in PubMed for myofascial pain syndrome. Research spans Clinical Trial Publication (43%), Review / Meta-Analysis (16%), and Basic Science / Preclinical (13%).
Research Type | Count | % of Total |
|---|---|---|
Clinical study results | 89 | 43% |
Research summaries | 33 | 16% |
Laboratory research | 27 | 13% |
Patient case studies | 19 | 9% |
Disease patterns and progression | 16 | 8% |
Testing and diagnosis research | 11 | 5% |
Other research | 9 | 4% |
New treatment approaches | 1 | 0% |
Mittal P (2026). [PMID: 42068432](https://pubmed.ncbi.nlm.nih.gov/42068432/). *Curr Pain Headache Rep*. [Review / Meta-Analysis]
Pinheiro RP (2026). [PMID: 41561444](https://pubmed.ncbi.nlm.nih.gov/41561444/). *Biomed Res Int*. [Basic Science / Preclinical]
Zhang Q (2026). [PMID: 41858807](https://pubmed.ncbi.nlm.nih.gov/41858807/). *J Pain Res*. [Basic Science / Preclinical]
Trybulski R (2026). [PMID: 41743538](https://pubmed.ncbi.nlm.nih.gov/41743538/). *Ther Adv Musculoskelet Dis*. [Clinical Trial Publication]
Koszela K (2026). [PMID: 41770355](https://pubmed.ncbi.nlm.nih.gov/41770355/). *Rheumatol Int*. [Clinical Trial Publication]
Zhu X (2026). [PMID: 41815725](https://pubmed.ncbi.nlm.nih.gov/41815725/). *Frontiers in neurology*. [Diagnostic / Biomarker]
Hu Z (2026). [PMID: 42087422](https://pubmed.ncbi.nlm.nih.gov/42087422/). *Med Sci Monit*. [Clinical Trial Publication]
Dey S (2026). [PMID: 41664327](https://pubmed.ncbi.nlm.nih.gov/41664327/). *Asian Spine J*. [Clinical Trial Publication]
Abu El Kasem ST (2026). [PMID: 41549044](https://pubmed.ncbi.nlm.nih.gov/41549044/). *Acupunct Med*. [Clinical Trial Publication]
Lin HW (2026). [PMID: 41166736](https://pubmed.ncbi.nlm.nih.gov/41166736/). *Disabil Rehabil*. [Review / Meta-Analysis]