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myelomeningocele - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

myelomeningocele

MONDO:0019773

Also known as:meningomyelocele

Find Clinical TrialsTrials

Overview

Myelomeningocele is the most severe form of spina bifida. It happens when parts of the spinal cord and nerves come through the open part of the spine. It causes nerve damage and other disabilities. Seventy to ninety percent of children with this condition also have too much fluid on their brains (hydrocephalus). This happens because fluid that protects the brain and spinal cord is unable to drain like it should. The fluid builds up, causing pressure and swelling. Without treatment, a persons head grows too big, and theymay have brain damage. Other disorders of the spinal cord may be seen, including syringomyelia and hip dislocation. The cause of myelomeningocele is unknown. However, low levels of folic acid in a woman's body before and during early pregnancy is thought to play a part in this type of birth defect.

Clinical Trials18 registered · 6 recruiting

Diagnosis

Biomarker and diagnostic research for myelomeningocele has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

18 clinical trials registered, 6 recruiting. Interventions under study include other interventions, medical devices, procedural interventions, and biologic therapy. Pipeline includes 1 PHASE1, 13 NA. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06042140](https://clinicaltrials.gov/study/NCT06042140)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 2:58 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:93969

GARD

Genetic and Rare Diseases Info Center

GARD:3475

Questions for Your Care Team

→Are any of the 18 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Research summaries	32	35%
Clinical study results	19	21%
Disease patterns and progression	18	20%
Laboratory research	9	10%
Patient case studies	6	7%
Other research	5	5%
Testing and diagnosis research	2	2%

Kisho

myelomeningocele

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Impact of Fetoscopic Surgery on the Myometrium: Experimental Study in an Ovine Model of Myelomeningocele.

myelomeningocele

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Impact of Fetoscopic Surgery on the Myometrium: Experimental Study in an Ovine Model of Myelomeningocele.