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A congenital abnormality in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.
Biomarker and diagnostic research for spina bifida cystica has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
21 clinical trials registered, 7 recruiting. Interventions under study include other interventions, medical devices, procedural interventions, and biologic therapy. Pipeline includes 1 PHASE1, 16 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT04652908](https://clinicaltrials.gov/study/NCT04652908) |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:55 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Cellular Therapy for In Utero Repair of Myelomeningocele - The CuRe Trial |
PHASE1 |
University of California, Davis |
RECRUITING |
[NCT06918119](https://clinicaltrials.gov/study/NCT06918119) | Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida | NA | Mayo Clinic | RECRUITING |
[NCT06929572](https://clinicaltrials.gov/study/NCT06929572) | Autologous Human Umbilical Cord Tissue Patch for Postnatal Closure of Open Neural Tube Defects | NA | The University of Texas Health Science Center, Houston | RECRUITING |
[NCT06796972](https://clinicaltrials.gov/study/NCT06796972) | In Utero Surgery for Fetal Myelomeningocele: Decision-making Mechanisms and Psychological Impact of Prenatal Therapy | NA | Assistance Publique - Hôpitaux de Paris | RECRUITING |
[NCT06042140](https://clinicaltrials.gov/study/NCT06042140) | Cryopreserved Human Umbilical Cord as a Meningeal Patch in Fetoscopic Spina Bifida Repair | NA | The University of Texas Health Science Center, Houston | RECRUITING |
215 publications have been identified in PubMed for spina bifida cystica. Kisho has analyzed 53 by research type. Research spans Review / Meta-Analysis (28%), Clinical Trial Publication (21%), and Epidemiology / Natural History (21%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 15 | 28% |
Clinical study results | 11 | 21% |
Disease patterns and progression | 11 | 21% |
Testing and diagnosis research | 6 | 11% |
Patient case studies | 5 | 9% |
Laboratory research | 4 | 8% |
Other research | 1 | 2% |
Koomen LR (2026). [PMID: 41790158](https://pubmed.ncbi.nlm.nih.gov/41790158/). *Childs Nerv Syst*. [Epidemiology / Natural History]
Familiari A (2026). [PMID: 41563074](https://pubmed.ncbi.nlm.nih.gov/41563074/). *Radiol Artif Intell*. [Diagnostic / Biomarker]
Clark M (2026). [PMID: 41848169](https://pubmed.ncbi.nlm.nih.gov/41848169/). *Dis Model Mech*. [Basic Science / Preclinical]
Keil C (2026). [PMID: 41298113](https://pubmed.ncbi.nlm.nih.gov/41298113/). *Prenat Diagn*. [Diagnostic / Biomarker]
Banh S (2026). [PMID: 41673379](https://pubmed.ncbi.nlm.nih.gov/41673379/). *Prenat Diagn*. [Clinical Trial Publication]
Kumar M (2026). [PMID: 40239713](https://pubmed.ncbi.nlm.nih.gov/40239713/). *Am J Perinatol*. [Diagnostic / Biomarker]
Bhandari J (2026). [PMID: 32310363](https://pubmed.ncbi.nlm.nih.gov/32310363/). *Unknown Journal*. [Epidemiology / Natural History]
Sahni M (2026). [PMID: 30725644](https://pubmed.ncbi.nlm.nih.gov/30725644/). *Unknown Journal*. [Clinical Trial Publication]
Van der Veeken L (2025). [PMID: 40120119](https://pubmed.ncbi.nlm.nih.gov/40120119/). *Ultrasound Obstet Gynecol*. [Epidemiology / Natural History]
Bowman R (2025). [PMID: 40368003](https://pubmed.ncbi.nlm.nih.gov/40368003/). *Am J Obstet Gynecol MFM*. [Case Report / Case Series]
AI-curated news mentioning spina bifida cystica
Updated Mar 16, 2026
The CDC highlights the importance of independence for individuals with spina bifida as they transition into adulthood. This focus on self-management of health care is crucial for improving quality of life.
The CDC highlights health issues and treatment options for children with spina bifida, aiming to raise awareness and improve care. This initiative focuses on educating families and healthcare providers about the condition.