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Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for neonatal-onset severe multisystemic autoinflammatory disease with increased IL18.
1 publication has been identified in PubMed for neonatal-onset severe multisystemic autoinflammatory disease with increased IL18. Research spans Case Report / Case Series (100%).
Ando T (2024). [PMID: 38036300](https://pubmed.ncbi.nlm.nih.gov/38036300/). *Modern rheumatology case reports*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:47 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center