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Fevers of unknown etiology recurring over months or years.
1 FDA-approved treatment is available for periodic fever syndrome, including CANAKINUMAB (ILARIS, approved 2009).
Brand Name | Generic Name | Mechanism | Approved | Market Status |
|---|---|---|---|---|
ILARIS | CANAKINUMAB | — | 2009 | Available |
1 clinical trial registered, 1 recruiting. Interventions under study include biologic therapy. Research is primarily industry-sponsored.
39 publications have been identified in PubMed for periodic fever syndrome. Research spans Case Report / Case Series (41%), Review / Meta-Analysis (26%), and Basic Science / Preclinical (18%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 16 | 41% |
Data assembled from 5 of 12 sources · Last updated Sep 21, 2026, 12:13 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
1 trial found
Research summaries |
10 |
26% |
Laboratory research | 7 | 18% |
Disease patterns and progression | 3 | 8% |
Clinical study results | 2 | 5% |
Other research | 1 | 3% |
Tetik Dinçer B (2026). [PMID: 41897084](https://pubmed.ncbi.nlm.nih.gov/41897084/). *Children (Basel)*. [Epidemiology / Natural History]
Oshima K (2026). [PMID: 40533175](https://pubmed.ncbi.nlm.nih.gov/40533175/). *The Tohoku journal of experimental medicine*. [Case Report / Case Series]
Kurihara M (2026). [PMID: 40571583](https://pubmed.ncbi.nlm.nih.gov/40571583/). *Journal of Nippon Medical School = Nippon Ika Daigaku zasshi*. [Case Report / Case Series]
Ugurlu S (2026). [PMID: 41480953](https://pubmed.ncbi.nlm.nih.gov/41480953/). *Balkan medical journal*. [Review / Meta-Analysis]
Dipasquale RF (2026). [PMID: 41495479](https://pubmed.ncbi.nlm.nih.gov/41495479/). *European journal of pediatrics*. [Basic Science / Preclinical]
Yao H (2026). [PMID: 41890736](https://pubmed.ncbi.nlm.nih.gov/41890736/). *Front Immunol*. [Case Report / Case Series]
Committee of Chinese Primary Health Care Foundation for Rheumatologists and Immunologists (2026). [PMID: 41946584](https://pubmed.ncbi.nlm.nih.gov/41946584/). *Zhonghua Yi Xue Za Zhi*. [Review / Meta-Analysis]
Tripathy SK (2025). [PMID: 40376361](https://pubmed.ncbi.nlm.nih.gov/40376361/). *Cureus*. [Review / Meta-Analysis]
Parvathy K (2025). [PMID: 41425676](https://pubmed.ncbi.nlm.nih.gov/41425676/). *Cureus*. [Case Report / Case Series]
Ömercioğlu E (2025). [PMID: 41276655](https://pubmed.ncbi.nlm.nih.gov/41276655/). *European journal of pediatrics*. [Review / Meta-Analysis]
AI-curated news mentioning periodic fever syndrome
Updated Apr 24, 2026
A recent study investigates the potential link between PFAPA syndrome and Behçet's disease in the Druze population of Israel. This research could enhance understanding of these conditions and their interrelation.