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Sarcoidosis is a multisystemic inflammatory disorder of unknown cause characterized by the formation of immune granulomas in affected organs, as stated in the packet definition. The condition occurs at an estimated prevalence of 1 to 5 individuals per 10,000 in the general population (Orphanet). Eight recognized subtypes are documented in this packet: Blau syndrome, neurosarcoidosis, skin sarcoidosis, hypercalcemic sarcoidosis, pulmonary sarcoidosis, Löfgren syndrome, uveoparotid fever, and cardiac sarcoidosis.
Detailed phenotype data are not present in this packet. The packet definition describes sarcoidosis as a multisystemic disorder, indicating that clinical features reflect the organs in which granulomas form. The range and frequency of specific symptoms are not enumerated in the available data fields.
The cause of sarcoidosis is documented as unknown in the packet definition. No causative genes are listed; the known_genes field is empty. Immune granuloma formation is described as the pathological hallmark, but the initiating stimulus is not identified in the available packet data. No inheritance pattern is recorded.
Diagnostic criteria and testing approaches for sarcoidosis are not enumerated in this packet. The condition is characterized as a multisystemic disorder requiring recognition of immune granuloma formation in involved organs, per the definition. Specific diagnostic protocols, imaging criteria, and tissue sampling requirements are not described in the available data fields.
No FDA-approved treatments are listed in this packet. The approved_treatments field and orphan drug entries for sarcoidosis are absent from the available data, reflecting the current regulatory landscape for this condition as documented in the packet.
79 trials found
Outcome and prognosis data are not present in this packet. Clinical course information, remission rates, and long-term trajectory are not enumerated in the available data fields for sarcoidosis.
Ten clinical trials involving sarcoidosis are listed as active or recruiting in this packet. Documented examples include a Phase 2 study of XTMAB-16 in pulmonary sarcoidosis with or without extrapulmonary manifestations by Xentria, Inc. (NCT07680166, not yet recruiting, projected completion 2029) and a Phase 2 study of brepocitinib in cutaneous sarcoidosis by Priovant Therapeutics (NCT06978725, recruiting, start 2025, projected completion 2029). Eight recognized disease subtypes indicate investigational heterogeneity within the condition.
Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 3:00 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
AI-curated news mentioning sarcoidosis
Updated Sep 11, 2026
A recent study highlights pediatric hepatic sarcoidosis as a rare cause of hypersplenism and portal hypertension in children. This discovery emphasizes the need for awareness and further research into this uncommon presentation.
A recent study published in PubMed explores external genital cutaneous sarcoidosis, which can mimic lichen sclerosus, highlighting the diagnostic challenges in differentiating between these conditions. This research contributes to the understanding of sarcoidosis presentations in dermatology.
A case report highlights secondary hemophagocytic lymphohistiocytosis in an immunocompetent adult, emphasizing the need to differentiate between sarcoidosis and histoplasmosis. This research contributes to the understanding of complex presentations in rare diseases.