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Infection of the brain or spinal cord by Treponema pallidum. It occurs many years following the original infection which remained untreated. Signs and symptoms include abnormal gait, blindness, depression, paralysis, seizures and dementia.
Biomarker and diagnostic research for neurosyphilis has been reported in the published literature.
2 clinical trials registered, 2 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.
220 publications have been identified in PubMed for neurosyphilis. Kisho has analyzed 158 by research type. Research spans Case Report / Case Series (31%), Review / Meta-Analysis (29%), and Diagnostic / Biomarker (16%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 49 |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 12:58 PM UTC
Genetic and Rare Diseases Info Center
Research summaries | 46 | 29% |
Testing and diagnosis research | 25 | 16% |
Disease patterns and progression | 19 | 12% |
Laboratory research | 13 | 8% |
Other research | 3 | 2% |
Clinical study results | 3 | 2% |
Yu H (2026). [PMID: 41563128](https://pubmed.ncbi.nlm.nih.gov/41563128/). *Infection and immunity*. [Review / Meta-Analysis]
Bai D (2026). [PMID: 41906088](https://pubmed.ncbi.nlm.nih.gov/41906088/). *BMC Neurol*. [Case Report / Case Series]
Tekiner H (2026). [PMID: 42148461](https://pubmed.ncbi.nlm.nih.gov/42148461/). *J Hist Neurosci*. [Review / Meta-Analysis]
Dai J (2026). [PMID: 42170220](https://pubmed.ncbi.nlm.nih.gov/42170220/). *Ther Clin Risk Manag*. [Clinical Trial Publication]
Jiang Y (2026). [PMID: 41914784](https://pubmed.ncbi.nlm.nih.gov/41914784/). *Emerg Microbes Infect*. [Diagnostic / Biomarker]
Garg RK (2026). [PMID: 41493643](https://pubmed.ncbi.nlm.nih.gov/41493643/). *Neurol Sci*. [Review / Meta-Analysis]
London F (2026). [PMID: 41701463](https://pubmed.ncbi.nlm.nih.gov/41701463/). *Acta Neurol Belg*. [Other]
Demirbas ND (2026). [PMID: 41774527](https://pubmed.ncbi.nlm.nih.gov/41774527/). *Int J STD AIDS*. [Basic Science / Preclinical]
Ren Y (2026). [PMID: 41123291](https://pubmed.ncbi.nlm.nih.gov/41123291/). *QJM*. [Epidemiology / Natural History]
Shruti (2026). [PMID: 41926293](https://pubmed.ncbi.nlm.nih.gov/41926293/). *Curr Neurovasc Res*. [Review / Meta-Analysis]
AI-curated news mentioning neurosyphilis
Updated May 8, 2026
A recent study highlights the diagnostic challenges of neurosyphilis, particularly when it presents with cortical ribboning and periodic EEG discharges. This research underscores the need for heightened awareness and improved diagnostic criteria for this rare manifestation.