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nevus of Ito - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

nevus of Ito

MONDO:0016985

Also known as:Ito's Nevusnevi of Itonevus fuscocaeruleus acromiodeltoideus

Overview

Nevus of Ito is a benign dermal melanocytosis occurring most frequently in the Asian populations and characterized by unilateral, asymptomatic, blue, gray or brown skin pigmentation within the acromioclavicular and upper chest area (involving the side of the neck, the supraclavicular and scapular areas, and the shoulder region). It is usually diagnosed in early infancy and in early adolescence. Nevus of Ito may progressively enlarge and darken in color (particularly with puberty) and its appearance usually remains stable once adulthood is reached. Spontaneous regression does not occur. Malignant melanoma has rarely been reported within a nevus of Ito. It shares the clinical features of nevus of Ota, except its anatomic location and may in rare occasions occur together with the latter.

ResearchLimited published research (8 articles)

Clinical Presentation

Features include very common findings: Nevus; and rarely findings: Cutaneous melanoma.

Explore clinical features

Prognosis

Phenotype severity distribution: 1 very common feature.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for nevus of Ito.

8 publications have been identified in PubMed for nevus of Ito. Research spans Case Report / Case Series (50%), Review / Meta-Analysis (38%), and Basic Science / Preclinical (13%).

Recent Publications

Castillon E (2026). [PMID: 42206741](https://pubmed.ncbi.nlm.nih.gov/42206741/). *Clin Genet*. [Basic Science / Preclinical]
Xie X (2026). [PMID: 41869419](https://pubmed.ncbi.nlm.nih.gov/41869419/). *Clin Cosmet Investig Dermatol*. [Case Report / Case Series]
Agarwal P (2026). [PMID: 32809409](https://pubmed.ncbi.nlm.nih.gov/32809409/). *Unknown Journal*. [Review / Meta-Analysis]
Gao B (2025). [PMID: 40950988](https://pubmed.ncbi.nlm.nih.gov/40950988/). *Front Med (Lausanne)*. [Case Report / Case Series]
Alqahtani J (2025). [PMID: 40606239](https://pubmed.ncbi.nlm.nih.gov/40606239/). *Acta Inform Med*. [Review / Meta-Analysis]
Huang M (2025). [PMID: 40458681](https://pubmed.ncbi.nlm.nih.gov/40458681/). *Clin Case Rep*. [Case Report / Case Series]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:12 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:263432

GARD

Genetic and Rare Diseases Info Center

GARD:10830

Questions for Your Care Team

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nevus of Ito

Overview

Clinical Presentation

Explore clinical features

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team