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nodular regenerative hyperplasia of the liver - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

nodular regenerative hyperplasia of the liver

MONDO:0018835

Also known as:non-cirrhotic nodulationmiliary hepatocellular adenomatosisnodular regenerative hyperplasia

Find Clinical TrialsTrials

Overview

Nodular regenerative hyperplasia of the liver is a rare parenchymatous liver disease characterized by diffuse benign transformation of the hepatic parenchyma into multiple small nodules (composed of regenerating hepatocytes) and that is usually asymptomatic but can lead to the development of non-cirrhotic portal hypertension and its complications, including esophageal variceal bleeding, hypersplenism and ascites. It is often associated with rheumatologic, autoimmune, hematologic, and myeloproliferative disorders as well as various immune deficiency states and exposure certain drugs and toxins.

Clinical Trials7 registered · 5 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Abnormality of the hepatic vasculature; and sometimes findings: Portal hypertension.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	2	Portal hypertension, Abnormality of the hepatic vasculature

Diagnosis

Biomarker and diagnostic research for nodular regenerative hyperplasia of the liver has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 very common feature.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

7 clinical trials registered, 5 recruiting. Interventions under study include other interventions, medical devices, and procedural interventions. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06500403](https://clinicaltrials.gov/study/NCT06500403)

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 9:10 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:48372

GARD

Genetic and Rare Diseases Info Center

GARD:10929

Questions for Your Care Team

→Are any of the 7 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	23	28%
Patient case studies	21	26%
Disease patterns and progression	14	17%
Testing and diagnosis research	13	16%
Laboratory research	7	9%
Other research	3	4%
Clinical study results	1	1%

Kisho

nodular regenerative hyperplasia of the liver

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

nodular regenerative hyperplasia of the liver

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications