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Left ventricular non-compaction (LVNC) is characterized by prominent left ventricular trabeculae and deep inter-trabecular recesses. The myocardial wall is often thickened with a thin, compacted epicardial layer and a thickened endocardial layer. In some patients, LVNC is associated with left ventricular dilatation and systolic dysfunction, which can be transient in neonates.
Biomarker and diagnostic research for non-compaction cardiomyopathy has been reported in the published literature.
4 clinical trials registered, 2 recruiting. Interventions under study include other interventions. Research is sponsored by a mix of industry and academic institutions.
50 publications have been identified in PubMed for non-compaction cardiomyopathy. Research spans Case Report / Case Series (38%), Review / Meta-Analysis (22%), and Basic Science / Preclinical (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 19 | 38% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 1:09 PM UTC
Research summaries |
11 |
22% |
Laboratory research | 7 | 14% |
Disease patterns and progression | 6 | 12% |
Testing and diagnosis research | 3 | 6% |
Other research | 2 | 4% |
Clinical study results | 1 | 2% |
New treatment approaches | 1 | 2% |
Posite CM (2026). [PMID: 41736986](https://pubmed.ncbi.nlm.nih.gov/41736986/). *Int Med Case Rep J*. [Case Report / Case Series]
Ramazani N (2026). [PMID: 41827439](https://pubmed.ncbi.nlm.nih.gov/41827439/). *Journal of clinical medicine*. [Review / Meta-Analysis]
Chen Y (2026). [PMID: 41918692](https://pubmed.ncbi.nlm.nih.gov/41918692/). *Front Pediatr*. [Case Report / Case Series]
Orbach R (2026). [PMID: 42135902](https://pubmed.ncbi.nlm.nih.gov/42135902/). *Ann Clin Transl Neurol*. [Diagnostic / Biomarker]
Zhang J (2026). [PMID: 41830141](https://pubmed.ncbi.nlm.nih.gov/41830141/). *Comb Chem High Throughput Screen*. [Gene Therapy / Novel Therapeutics]
Tumkur Panduranga V (2026). [PMID: 41873321](https://pubmed.ncbi.nlm.nih.gov/41873321/). *Cureus*. [Case Report / Case Series]
Zhao Y (2026). [PMID: 41705901](https://pubmed.ncbi.nlm.nih.gov/41705901/). *Prenat Diagn*. [Basic Science / Preclinical]
Mirchuk M (2025). [PMID: 40309756](https://pubmed.ncbi.nlm.nih.gov/40309756/). *Echocardiography (Mount Kisco, N.Y.)*. [Review / Meta-Analysis]
Yigit G (2025). [PMID: 40207042](https://pubmed.ncbi.nlm.nih.gov/40207042/). *Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V*. [Review / Meta-Analysis]
Monteiro JP (2025). [PMID: 40183391](https://pubmed.ncbi.nlm.nih.gov/40183391/). *Cardiovascular research*. [Basic Science / Preclinical]
AI-curated news mentioning non-compaction cardiomyopathy
Updated Jan 27, 2026
A recent case study highlights an infant with double-chambered left ventricle and extensive non-compaction, identified through intraoperative endoscopy. This discovery may enhance understanding of cardiac anomalies in pediatric patients.