Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

non-involuting congenital hemangioma (NICH) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

non-involuting congenital hemangioma

MONDO:0015403

Also known as:NICHnoninvoluting congenital hemangioma

Overview

Non-involuting congenital hemangioma (NICH) is a rare type of infantile hemangioma, which is a tumor that forms from the abnormal growth of blood vessels in the skin. NICH looks like an oval,purplish mark or bump that can occur on any part of the body. NICH is present from birth (congenital) and increases in size as the child grows. Unlike other hemangiomas, NICH do not disappear spontaneously (involute).

ResearchLimited published research (6 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Hemangioma; and common findings: Midfrontal capillary hemangioma, Subcutaneous calcification, Perineal hemangioma, and Visible small blood vessels on skin (telangiectasia of the skin). 11 total HPO annotations.

Organ System	Phenotype Count	Example Features
Skin	2	Subcutaneous calcification, Visible small blood vessels on skin (telangiectasia of the skin)

Diagnosis

Biomarker and diagnostic research for non-involuting congenital hemangioma has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 always present feature, 4 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for non-involuting congenital hemangioma.

6 publications have been identified in PubMed for non-involuting congenital hemangioma. Research spans Case Report / Case Series (67%), Diagnostic / Biomarker (17%), and Gene Therapy / Novel Therapeutics (17%).

Recent Publications

Topal E (2026). [PMID: 41795659](https://pubmed.ncbi.nlm.nih.gov/41795659/). *Pediatric dermatology*. [Case Report / Case Series]
Meara EM (2026). [PMID: 41923709](https://pubmed.ncbi.nlm.nih.gov/41923709/). *Pediatr Dermatol*. [Case Report / Case Series]
Estefanía-Fernández K (2025). [PMID: 40723086](https://pubmed.ncbi.nlm.nih.gov/40723086/). *Children (Basel, Switzerland)*. [Case Report / Case Series]
Li Y (2025). [PMID: 40894922](https://pubmed.ncbi.nlm.nih.gov/40894922/). *Frontiers in cell and developmental biology*. [Gene Therapy / Novel Therapeutics]
Marcelin C (2024). [PMID: 38853199](https://pubmed.ncbi.nlm.nih.gov/38853199/). *Insights into imaging*. [Diagnostic / Biomarker]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 10:41 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:141179

GARD

Genetic and Rare Diseases Info Center

GARD:10890

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

non-involuting congenital hemangioma

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features