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Odonto-tricho-ungual-digito-palmar syndrome is characterized by neonatal teeth, trichodystrophy and malformations of the hands and feet. To date, it has been reported in 21 patients and is transmitted as an autosomal dominant trait.
Features include: Natal tooth, Brachydactyly, Nail dysplasia, and Hypopigmentation of the skin and 11 more.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 3 | Nail dysplasia, Hypopigmentation of the skin, Nail dystrophy |
Arms and legs |
Biomarker and diagnostic research for odonto-tricho-ungual-digito-palmar syndrome has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for odonto-tricho-ungual-digito-palmar syndrome.
289 publications have been identified in PubMed for odonto-tricho-ungual-digito-palmar syndrome. Kisho has analyzed 100 by research type. Research spans Review / Meta-Analysis (70%), Basic Science / Preclinical (14%), and Epidemiology / Natural History (8%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 70 | 70% |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 6:38 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
2
Short distal phalanx of finger, Short distal phalanx of toe |
Head and neck | 1 | Mandibular prognathia |
Laboratory research |
14 |
14% |
Disease patterns and progression | 8 | 8% |
Patient case studies | 3 | 3% |
Other research | 2 | 2% |
Clinical study results | 2 | 2% |
Testing and diagnosis research | 1 | 1% |
Amado C (2026). [PMID: 40975490](https://pubmed.ncbi.nlm.nih.gov/40975490/). *Ann Allergy Asthma Immunol*. [Review / Meta-Analysis]
Papazachariou A (2026). [PMID: 41128447](https://pubmed.ncbi.nlm.nih.gov/41128447/). *Curr Opin Clin Nutr Metab Care*. [Review / Meta-Analysis]
Anderson EN (2026). [PMID: 41468891](https://pubmed.ncbi.nlm.nih.gov/41468891/). *Am J Hum Genet*. [Clinical Trial Publication]
Cornejo-Sanchez DM (2025). [PMID: 40055553](https://pubmed.ncbi.nlm.nih.gov/40055553/). *Eur J Hum Genet*. [Basic Science / Preclinical]
Mutai H (2025). [PMID: 39755840](https://pubmed.ncbi.nlm.nih.gov/39755840/). *Hum Genet*. [Basic Science / Preclinical]
Dotan A (2025). [PMID: 39931017](https://pubmed.ncbi.nlm.nih.gov/39931017/). *Harefuah*. [Review / Meta-Analysis]
Yacoub MR (2025). [PMID: 40747632](https://pubmed.ncbi.nlm.nih.gov/40747632/). *Curr Opin Allergy Clin Immunol*. [Review / Meta-Analysis]
Bonniaud V (2025). [PMID: 40546152](https://pubmed.ncbi.nlm.nih.gov/40546152/). *Rev Prat*. [Review / Meta-Analysis]
Pena C (2025). [PMID: 40146047](https://pubmed.ncbi.nlm.nih.gov/40146047/). *Minerva Med*. [Review / Meta-Analysis]
Gencer NS (2025). [PMID: 41291504](https://pubmed.ncbi.nlm.nih.gov/41291504/). *BMC Geriatr*. [Epidemiology / Natural History]