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oral cavity squamous cell carcinoma - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

oral cavity squamous cell carcinoma

MONDO:0004958

Also known as:mouth sccmouth squamous cell carcinomaoral cavity scc

Find Clinical TrialsTrials

Overview

A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status.

Clinical Trials93 registered · 35 recruiting

Diagnosis

Biomarker and diagnostic research for oral cavity squamous cell carcinoma has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

93 clinical trials registered, 35 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and biologic therapy. Pipeline includes 6 PHASE3, 40 PHASE2, 13 PHASE1. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06321003](https://clinicaltrials.gov/study/NCT06321003)

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 4:05 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:502363

GARD

Genetic and Rare Diseases Info Center

GARD:17932

Questions for Your Care Team

→Are any of the 93 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Clinical study results	59	25%
Disease patterns and progression	55	23%
Testing and diagnosis research	47	20%
Laboratory research	33	14%
Research summaries	20	9%
Patient case studies	12	5%
Other research	9	4%

Kisho

oral cavity squamous cell carcinoma

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

A Rare Case of Cutaneous Metastasis From Oral Squamous Cell Carcinoma (OSCC) and the Possible Role of GALR2 as a Biomarker: A Case Report.

Unusual Cardiac Metastasis from Oral Squamous Cell Carcinoma: A Case Report and Literature Review.

Synchronous occurrence of oral squamous cell carcinoma and aggressive papillary thyroid microcarcinoma with synchronous regional metastasis in the cervical lymph nodes: a case report.

oral cavity squamous cell carcinoma

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

A Rare Case of Cutaneous Metastasis From Oral Squamous Cell Carcinoma (OSCC) and the Possible Role of GALR2 as a Biomarker: A Case Report.

Unusual Cardiac Metastasis from Oral Squamous Cell Carcinoma: A Case Report and Literature Review.

Synchronous occurrence of oral squamous cell carcinoma and aggressive papillary thyroid microcarcinoma with synchronous regional metastasis in the cervical lymph nodes: a case report.