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A benign, usually self-limited fibro-osseous lesion of the bone that affects infants and children. It usually arises from the cortical bone of the anterior mid-shaft of the tibia. Patients usually present with swelling or painless bowing of the tibia. Progression to adamantinoma has been reported in some cases.
Features include always present findings: Pathologic fracture; and sometimes findings: Fibular hypoplasia and Pectus excavatum. 4 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Bones and joints | 1 | Pathologic fracture |
Age of onset: childhood.
Biomarker and diagnostic research for osteofibrous dysplasia has been reported in the published literature.
Phenotype severity distribution: 1 always present feature.
No clinical trials have been registered for osteofibrous dysplasia.
168 publications have been identified in PubMed for osteofibrous dysplasia. Kisho has analyzed 134 by research type. Research spans Case Report / Case Series (36%), Review / Meta-Analysis (23%), and Diagnostic / Biomarker (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 48 | 36% |
Data assembled from 5 of 12 sources · Last updated Sep 21, 2026, 11:08 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries
31 |
23% |
Testing and diagnosis research | 17 | 13% |
Laboratory research | 15 | 11% |
Clinical study results | 12 | 9% |
Disease patterns and progression | 5 | 4% |
Other research | 4 | 3% |
New treatment approaches | 2 | 1% |
Souza MRF (2026). [PMID: 41266198](https://pubmed.ncbi.nlm.nih.gov/41266198/). *Oral Surg Oral Med Oral Pathol Oral Radiol*. [Case Report / Case Series]
Jayan R (2026). [PMID: 40539236](https://pubmed.ncbi.nlm.nih.gov/40539236/). *Histol Histopathol*. [Review / Meta-Analysis]
Wise KL (2026). [PMID: 41627625](https://pubmed.ncbi.nlm.nih.gov/41627625/). *Head Neck Pathol*. [Review / Meta-Analysis]
Saoud C (2026). [PMID: 41203137](https://pubmed.ncbi.nlm.nih.gov/41203137/). *Mod Pathol*. [Case Report / Case Series]
Dong R (2026). [PMID: 41708313](https://pubmed.ncbi.nlm.nih.gov/41708313/). *J Clin Pathol*. [Basic Science / Preclinical]
Ahmed S (2026). [PMID: 42273478](https://pubmed.ncbi.nlm.nih.gov/42273478/). *J Orthop Case Rep*. [Case Report / Case Series]
Baltacioglu MH (2026). [PMID: 42257449](https://pubmed.ncbi.nlm.nih.gov/42257449/). *Clin Nucl Med*. [Case Report / Case Series]
Wang Y (2026). [PMID: 41633608](https://pubmed.ncbi.nlm.nih.gov/41633608/). *Beijing Da Xue Xue Bao Yi Xue Ban*. [Case Report / Case Series]
Debus J (2026). [PMID: 41483304](https://pubmed.ncbi.nlm.nih.gov/41483304/). *Eur J Nucl Med Mol Imaging*. [Diagnostic / Biomarker]
Dewara ND (2026). [PMID: 41878296](https://pubmed.ncbi.nlm.nih.gov/41878296/). *Case Reports Plast Surg Hand Surg*. [Case Report / Case Series]
AI-curated news mentioning osteofibrous dysplasia
Updated Feb 14, 2026
A recent study published in PubMed discusses the treatment and management of osteofibrous dysplasia like adamantinoma, providing insights from a single institution's experience. This research contributes to the understanding of this rare bone condition.