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A sarcomatous transformation of pre-existing Paget disease of the bone. Osteosarcomas arising from Paget disease of the bone are high grade lesions and usually have a poor prognosis.
No clinical trials have been registered for osteosarcoma arising in bone Paget disease.
4 publications have been identified in PubMed for osteosarcoma arising in bone Paget disease. Research spans Case Report / Case Series (75%) and Epidemiology / Natural History (25%).
Bogojevska Doksevska M (2025). [PMID: 39802336](https://pubmed.ncbi.nlm.nih.gov/39802336/). *Journal of surgical case reports*. [Case Report / Case Series]
Gaiani F (2025). [PMID: 40064000](https://pubmed.ncbi.nlm.nih.gov/40064000/). *Journal of neurosurgery. Case lessons*. [Case Report / Case Series]
De La Fuente M (2025). [PMID: 39926564](https://pubmed.ncbi.nlm.nih.gov/39926564/). *European journal of case reports in internal medicine*. [Case Report / Case Series]
Kar E (2024). [PMID: 38975333](https://pubmed.ncbi.nlm.nih.gov/38975333/). *Journal of bone oncology*. [Epidemiology / Natural History]
Data assembled from 2 of 12 sources · Last updated Sep 20, 2026, 11:09 AM UTC
AI-curated news mentioning osteosarcoma arising in bone Paget disease
Updated Aug 16, 2026
Recent research highlights two cases of giant cell tumors of the orbit, including one associated with Paget's disease of bone. These findings contribute to the understanding of the clinical presentation and implications of these rare tumors.
Recent research highlights the pathogenesis and ocular manifestations of Paget's disease of bone, offering insights into potential therapeutic strategies. This study contributes to the understanding of the disease's complexities and treatment options.