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A low grade malignant neoplasm arising from the long bones. The tibia is the most frequently affected bone site. Patients present with swelling which may or may not be associated with pain. Morphologically, it is characterized by a biphasic pattern consisting of an epithelial and an osteofibrous component. The vast majority of cases recur if they are not treated with radical surgery. In a minority of cases the tumor may metastasize to other anatomic sites including lymph nodes, lungs, liver, brain, and skeleton.
Features include: Neoplasm.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Neoplasm | 1 | Neoplasm |
Estimated prevalence: Unknown (Unknown prevalence).
4 clinical trials registered, 2 recruiting. Interventions under study include drug therapy. Pipeline includes 2 PHASE2, 1 PHASE1, 1 EARLY_PHASE1. Research is sponsored by a mix of industry and academic institutions.
56 publications have been identified in PubMed for adamantinoma. Research spans Case Report / Case Series (59%), Review / Meta-Analysis (20%), and Clinical Trial Publication (11%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 33 |
Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 5:23 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about adamantinoma
Research summaries | 11 | 20% |
Clinical study results | 6 | 11% |
Disease patterns and progression | 3 | 5% |
Laboratory research | 2 | 4% |
New treatment approaches | 1 | 2% |
Wu XM (2026). [PMID: 42266005](https://pubmed.ncbi.nlm.nih.gov/42266005/). *Fetal Pediatr Pathol*. [Clinical Trial Publication]
Faquih AE (2026). [PMID: 41927126](https://pubmed.ncbi.nlm.nih.gov/41927126/). *BMJ case reports*. [Case Report / Case Series]
Allen DZ (2026). [PMID: 41834435](https://pubmed.ncbi.nlm.nih.gov/41834435/). *Head & neck*. [Case Report / Case Series]
Eng TY (2026). [PMID: 41391901](https://pubmed.ncbi.nlm.nih.gov/41391901/). *Seminars in radiation oncology*. [Review / Meta-Analysis]
Han XP (2026). [PMID: 41490637](https://pubmed.ncbi.nlm.nih.gov/41490637/). *Zhonghua bing li xue za zhi = Chinese journal of pathology*. [Case Report / Case Series]
Martheswaran T (2026). [PMID: 41632692](https://pubmed.ncbi.nlm.nih.gov/41632692/). *International journal of surgical pathology*. [Case Report / Case Series]
Jayan R (2026). [PMID: 40539236](https://pubmed.ncbi.nlm.nih.gov/40539236/). *Histology and histopathology*. [Review / Meta-Analysis]
Jayan R (2026). [PMID: 41653544](https://pubmed.ncbi.nlm.nih.gov/41653544/). *Annals of diagnostic pathology*. [Epidemiology / Natural History]
Lépine C (2026). [PMID: 41702743](https://pubmed.ncbi.nlm.nih.gov/41702743/). *European annals of otorhinolaryngology, head and neck diseases*. [Clinical Trial Publication]
Wong LH (2026). [PMID: 41439258](https://pubmed.ncbi.nlm.nih.gov/41439258/). *Journal of hand surgery global online*. [Case Report / Case Series]
AI-curated news mentioning adamantinoma
Updated Feb 14, 2026
A recent study published in PubMed discusses the treatment and management of osteofibrous dysplasia like adamantinoma, providing insights from a single institution's experience. This research contributes to the understanding of this rare bone condition.